Document Detail


Serum inflammatory mediators in pregnancy: changes after periodontal treatment and association with pregnancy outcomes.
MedLine Citation:
PMID:  19905943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The purposes of this study were to determine: 1) if periodontal treatment in pregnant women before 21 weeks of gestation alters levels of inflammatory mediators in serum; and 2) if changes in these mediators are associated with birth outcomes.
METHODS: A total of 823 pregnant women with periodontitis were randomly assigned to receive scaling and root planing before 21 weeks of gestation or after delivery. Serum obtained between 13 and 16 weeks, 6 days (study baseline) and 29 to 32 weeks of gestation was analyzed for C-reactive protein; prostaglandin E(2); matrix metalloproteinase-9; fibrinogen; endotoxin; interleukin (IL)-1 beta, -6, and -8, and tumor necrosis factor-alpha. Cox regression, multiple linear regression, and the t, chi(2), and Fisher exact tests were used to examine associations among the biomarkers, periodontal treatment, and gestational age at delivery and birth weight.
RESULTS: A total of 796 women had baseline serum data, and 620 women had baseline and follow-up serum and birth data. Periodontal treatment did not significantly alter the level of any biomarker (P >0.05). Neither baseline levels nor the change from baseline in any biomarker were significantly associated with preterm birth or infant birth weight (P >0.05). In treatment subjects, the change in endotoxin was negatively associated with the change in probing depth (P <0.05).
CONCLUSIONS: Non-surgical mechanical periodontal treatment in pregnant women, delivered before 21 weeks of gestation, did not reduce systemic (serum) markers of inflammation. In pregnant women with periodontitis, levels of these markers at 13 to 17 weeks and 29 to 32 weeks of gestation were not associated with infant birth weight or a risk for preterm birth.
Authors:
Bryan S Michalowicz; M John Novak; James S Hodges; Anthony DiAngelis; William Buchanan; Panos N Papapanou; Dennis A Mitchell; James E Ferguson; Virginia Lupo; James Bofill; Stephen Matseoane; Michelle Steffen; Jeffrey L Ebersole
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of periodontology     Volume:  80     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-12     Completed Date:  2009-12-22     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1731-41     Citation Subset:  D; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Birth Weight
C-Reactive Protein / analysis
Dental Scaling
Dinoprostone / blood
Endotoxins / blood
Female
Fibrinogen / analysis
Follow-Up Studies
Gestational Age
Humans
Infant, Newborn
Inflammation Mediators / blood*
Interleukin-1beta / blood
Interleukin-6 / blood
Interleukin-8 / blood
Matrix Metalloproteinase 9 / blood
Periodontitis / blood,  therapy*
Pregnancy
Pregnancy Complications / blood*,  therapy
Pregnancy Outcome*
Premature Birth / blood
Risk Factors
Root Planing
Tumor Necrosis Factor-alpha / blood
Young Adult
Grant Support
ID/Acronym/Agency:
U01 DE014338/DE/NIDCR NIH HHS; U01 DE014338-06/DE/NIDCR NIH HHS; UO1 DE014338/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Endotoxins; 0/Inflammation Mediators; 0/Interleukin-1beta; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; EC 3.4.24.35/Matrix Metalloproteinase 9; K7Q1JQR04M/Dinoprostone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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