| Serum inflammatory mediators in pregnancy: changes after periodontal treatment and association with pregnancy outcomes. | |
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MedLine Citation:
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PMID: 19905943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The purposes of this study were to determine: 1) if periodontal treatment in pregnant women before 21 weeks of gestation alters levels of inflammatory mediators in serum; and 2) if changes in these mediators are associated with birth outcomes. METHODS: A total of 823 pregnant women with periodontitis were randomly assigned to receive scaling and root planing before 21 weeks of gestation or after delivery. Serum obtained between 13 and 16 weeks, 6 days (study baseline) and 29 to 32 weeks of gestation was analyzed for C-reactive protein; prostaglandin E(2); matrix metalloproteinase-9; fibrinogen; endotoxin; interleukin (IL)-1 beta, -6, and -8, and tumor necrosis factor-alpha. Cox regression, multiple linear regression, and the t, chi(2), and Fisher exact tests were used to examine associations among the biomarkers, periodontal treatment, and gestational age at delivery and birth weight. RESULTS: A total of 796 women had baseline serum data, and 620 women had baseline and follow-up serum and birth data. Periodontal treatment did not significantly alter the level of any biomarker (P >0.05). Neither baseline levels nor the change from baseline in any biomarker were significantly associated with preterm birth or infant birth weight (P >0.05). In treatment subjects, the change in endotoxin was negatively associated with the change in probing depth (P <0.05). CONCLUSIONS: Non-surgical mechanical periodontal treatment in pregnant women, delivered before 21 weeks of gestation, did not reduce systemic (serum) markers of inflammation. In pregnant women with periodontitis, levels of these markers at 13 to 17 weeks and 29 to 32 weeks of gestation were not associated with infant birth weight or a risk for preterm birth. |
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Authors:
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Bryan S Michalowicz; M John Novak; James S Hodges; Anthony DiAngelis; William Buchanan; Panos N Papapanou; Dennis A Mitchell; James E Ferguson; Virginia Lupo; James Bofill; Stephen Matseoane; Michelle Steffen; Jeffrey L Ebersole |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of periodontology Volume: 80 ISSN: 1943-3670 ISO Abbreviation: J. Periodontol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-12 Completed Date: 2009-12-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
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Languages: eng Pagination: 1731-41 Citation Subset: D; IM |
Affiliation:
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Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, USA. micha002@umn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Birth Weight C-Reactive Protein / analysis Dental Scaling Dinoprostone / blood Endotoxins / blood Female Fibrinogen / analysis Follow-Up Studies Gestational Age Humans Infant, Newborn Inflammation Mediators / blood* Interleukin-1beta / blood Interleukin-6 / blood Interleukin-8 / blood Matrix Metalloproteinase 9 / blood Periodontitis / blood, therapy* Pregnancy Pregnancy Complications / blood*, therapy Pregnancy Outcome* Premature Birth / blood Risk Factors Root Planing Tumor Necrosis Factor-alpha / blood Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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U01 DE014338-06/DE/NIDCR NIH HHS; UO1 DE014338/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Inflammation Mediators; 0/Interleukin-1beta; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 363-24-6/Dinoprostone; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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