| Serum inflammatory markers and clinical/MRI markers of disease progression in multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 11499639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to assess whether mean serum levels of inflammatory markers when measured serially correlate with disease progression or putative MRI markers of axonal loss in a cohort of well-characterised multiple sclerosis (MS) patients. Serial serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), nitric oxide metabolites nitrate and nitrite (NOx), C-reactive protein (CRP), neopterin and tumour necrosis factor alpha (TNF-alpha) were measured in 29 MS patients, 13 with a relapsing remitting (RR) and 16 with a secondary progressive (SP) course, who were participating in a phase II clinical trial of anti-CD4 therapy. Short-term whole blood stimulated TNF-alpha production was also measured. Patients were studied 12 times over an 18-month period. MRI variables included the number and volume of Gd-enhancing lesions and the change in T2-hyperintense, T1-hypointense lesions and cerebral volume between the baseline and exit studies. Disease progression required a sustained change in the EDSS. There was no correlation between mean levels of inflammatory markers over the study period and disease progression or changes in any of the MRI measures. However, mean sICAM-1 levels from the first 6 months of the study were higher in patients who progressed during the study than in those that did not (443 (SD439) vs. 235 (SD162) ng/mL, p=0.05). Mean levels of NOx were significantly higher in patients with RR MS than in patients with SP disease (59.1 micromol/L (SD 12.8) vs. 48.7 micromol/L (SD 11.9), p=0.02). Patients with either a single relapse or no relapse had significantly higher NOx levels than to patients with multiple relapses during the 18 month follow-up (59.0 micromol/L (SD 12.3) vs. 47.9 micromol/L (SD 12.0), p=0.02). The mean levels of the other inflammatory markers did not correlate with disease course or relapse-rate. Serum levels of many inflammatory markers do not correlate with short-term disease progression. Some of the data suggest that the effects of inflammation on disease progression are delayed. In addition raised levels of serum nitric oxide metabolites are associated with a lower number of clinical relapses and a non-progressive disease course. These findings, although preliminary, pose interesting questions on the role of nitric oxide in the pathogenesis of MS. Inducible NO production in the early stages of the disease may be beneficial. |
| | |
Authors:
|
G Giovannoni; D H Miller; N A Losseff; M Sailer; N Lewellyn-Smith; A J Thompson; E J Thompson |
Related Documents
:
|
9559919 - Does glutamate mediate brain damage in acute encephalitis? 1320989 - Response of left ventricular ejection performance following balloon valvuloplasty in pa... 20935029 - Preferential increase of b-cell activating factor in the cerebrospinal fluid of neuromy... 15134719 - Motor cortex stimulation for amyotrophic lateral sclerosis. time for a therapeutic trial? 16155429 - Autonomic impairment in amyotrophic lateral sclerosis. 10321329 - Nociceptive r3 reflex in relapsing-remitting multiple sclerosis patients. 9774749 - Migraine with aura and right-to-left shunt on transcranial doppler: a case-control study. 9583849 - Biochemical assessment of the nutritional status of cystic fibrosis patients treated wi... 22992349 - Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabol... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of neurology Volume: 248 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2001 Jun |
Date Detail:
|
Created Date: 2001-08-13 Completed Date: 2001-12-12 Revised Date: 2011-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
|
Languages: eng Pagination: 487-95 Citation Subset: IM |
Affiliation:
|
Department of Neurochemistry, University of London, UK. G.Giovannoni@ion.ucl.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Axons / pathology Biological Markers / analysis* C-Reactive Protein / analysis Disease Progression Female Humans Inflammation / physiopathology* Intercellular Adhesion Molecule-1 / blood Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis / pathology* Nitric Oxide / blood Recurrence Tumor Necrosis Factor-alpha / analysis Vascular Cell Adhesion Molecule-1 / blood |
| Grant Support | |
ID/Acronym/Agency:
|
491//Multiple Sclerosis Society |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Tumor Necrosis Factor-alpha; 0/Vascular Cell Adhesion Molecule-1; 10102-43-9/Nitric Oxide; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term sensory deficit after Guillain-Barré syndrome.
Next Document: The SOX10 transcription factor: evaluation as a candidate gene for central and peripheral hereditary...