Document Detail


Serum inflammatory adhesion molecules and high-sensitivity C-reactive protein correlates with delayed ischemic neurologic deficits after subarachnoid hemorrhage.
MedLine Citation:
PMID:  18486699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The purpose of the present study was to investigate the relationship between serum concentrations of the immunoglobulin-like superfamily, selectins, hsCRP, and the development of DIND in patients with aneurysmal SAH. METHODS: Serum ICAM-1, VCAM-1, E-selectin, P-selectin, L-selectin, and hsCRP were measured in 33 patients with SAH who underwent aneurysmal clipping within 48 hours of the onset of symptoms. Serum samples were obtained during the early period (day 0) and the late period (day 7). RESULTS: The serum concentrations of ICAM-1 (P = .009), VCAM-1 (P = .0383) and hsCRP (P = .0014) during the early period were significantly higher in patients with SAH than in control patients. Further, serum hsCRP concentration during the late period was significantly higher in patients with SAH than in control patients (P = 0033). Finally, serum concentrations of ICAM-1, VCAM-1, and hsCRP during the early (P = .0055, P = .0266, and P = .0266) and late (P = .0423, P = .0041, and P = .0004) period were significantly higher in patients with DIND than in patients without DIND. CONCLUSIONS: Serum levels of ICAM-1, VCAM-1 and hsCRP during the early and late period following SAH correlate with DIND.
Authors:
Yoshitaka Kubo; Kuniaki Ogasawara; Shunsuke Kakino; Hiroshi Kashimura; Nobuhiko Tomitsuka; Atsushi Sugawara; Akira Ogawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgical neurology     Volume:  69     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  592-6; discussion 596     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Iwate Medical University, Morioka 020-8505, Japan. yokubo@iwate-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Aneurysm, Ruptured / blood,  complications,  surgery
Brain Ischemia / blood,  etiology*
C-Reactive Protein / metabolism*
Cell Adhesion Molecules / blood*
Cohort Studies
Female
Humans
Intracranial Aneurysm / blood,  complications,  surgery
Male
Middle Aged
Retrospective Studies
Selectins / blood*
Subarachnoid Hemorrhage / blood*,  complications*,  surgery
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Selectins; 9007-41-4/C-Reactive Protein

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