| Serum inflammatory adhesion molecules and high-sensitivity C-reactive protein correlates with delayed ischemic neurologic deficits after subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 18486699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The purpose of the present study was to investigate the relationship between serum concentrations of the immunoglobulin-like superfamily, selectins, hsCRP, and the development of DIND in patients with aneurysmal SAH. METHODS: Serum ICAM-1, VCAM-1, E-selectin, P-selectin, L-selectin, and hsCRP were measured in 33 patients with SAH who underwent aneurysmal clipping within 48 hours of the onset of symptoms. Serum samples were obtained during the early period (day 0) and the late period (day 7). RESULTS: The serum concentrations of ICAM-1 (P = .009), VCAM-1 (P = .0383) and hsCRP (P = .0014) during the early period were significantly higher in patients with SAH than in control patients. Further, serum hsCRP concentration during the late period was significantly higher in patients with SAH than in control patients (P = 0033). Finally, serum concentrations of ICAM-1, VCAM-1, and hsCRP during the early (P = .0055, P = .0266, and P = .0266) and late (P = .0423, P = .0041, and P = .0004) period were significantly higher in patients with DIND than in patients without DIND. CONCLUSIONS: Serum levels of ICAM-1, VCAM-1 and hsCRP during the early and late period following SAH correlate with DIND. |
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Authors:
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Yoshitaka Kubo; Kuniaki Ogasawara; Shunsuke Kakino; Hiroshi Kashimura; Nobuhiko Tomitsuka; Atsushi Sugawara; Akira Ogawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Surgical neurology Volume: 69 ISSN: 0090-3019 ISO Abbreviation: Surg Neurol Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-19 Completed Date: 2008-07-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0367070 Medline TA: Surg Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 592-6; discussion 596 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Iwate Medical University, Morioka 020-8505, Japan. yokubo@iwate-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aneurysm, Ruptured / blood, complications, surgery Brain Ischemia / blood, etiology* C-Reactive Protein / metabolism* Cell Adhesion Molecules / blood* Cohort Studies Female Humans Intracranial Aneurysm / blood, complications, surgery Male Middle Aged Retrospective Studies Selectins / blood* Subarachnoid Hemorrhage / blood*, complications*, surgery Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Selectins; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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