Document Detail

Serum-induced macrophage activation is related to the severity of septic shock.
MedLine Citation:
PMID:  19184359     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It seems that a balance between anti and pro-inflammatory responses must be kept to eliminate the pathogen without inducing inflammatory damage in the host. Thus we determined the relation between macrophage activation and the severity and clinical outcome in septic patients. MATERIAL AND METHODS: This was a prospective study at a tertiary general intensive care unit. Thirty-three patients admitted with sepsis, severe sepsis or septic shock were included. As a control group, healthy volunteers were included matched to septic patients by age and sex. Peritoneal rat macrophages were cultured with 2% serum from healthy volunteers or from septic patients for determination of phagocytic potential or the capacity to produce cytokines. RESULTS: TNF and IL1 secretion by macrophages activated with serum from sepsis and severe sepsis patients was higher than with serum from healthy controls. In addition, proinflammatory cytokines released in vitro from macrophages, but not determined directly in the serum from patients, were lower in non-survivor septic patients when compared to survivors. In contrast, IL-10 secretion by macrophages activated with serum from septic patients was higher in nonsurvivors. In the septic shock group we observed a diminution in the phagocytic index compared to sepsis and severe sepsis groups, and the phagocytic index was higher in sepsis survivors. CONCLUSIONS: Markers of antiinflammation are predominant in more severe types of sepsis suggesting that antiinflammation is related to mortality.
G Peck; M Andrades; R Lorenzi; M da Costa; F Petronilho; J C Fonseca Moreira; F Dal-Pizzol; C Ritter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammation research : official journal of the European Histamine Research Society ... [et al.]     Volume:  58     ISSN:  1420-908X     ISO Abbreviation:  Inflamm. Res.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-04-14     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  9508160     Medline TA:  Inflamm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Laborat?rio de Fisiopatologia Experimental, Programa de P?s-Gradua??o em Ci?ncias da Sa?de, Unidade Acad?mica de Ci?ncias da Sa?de, Universidade do Extremo Sul Catarinense, SC, Brazil.
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MeSH Terms
Aged, 80 and over
Cells, Cultured
Cytokines / blood,  immunology
Macrophage Activation*
Macrophages, Peritoneal / cytology,  immunology
Middle Aged
Nitric Oxide / metabolism
Prospective Studies
Rats, Wistar
Severity of Illness Index*
Shock, Septic* / blood,  immunology
Treatment Outcome
Reg. No./Substance:
0/Cytokines; 10102-43-9/Nitric Oxide

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