Document Detail

Serum immunoreactive erythropoietin and red blood cell mass during pregnancy in conscious rats.
MedLine Citation:
PMID:  8368394     Owner:  NLM     Status:  MEDLINE    
Serum erythropoietin concentration increases during human pregnancy and presumably accounts for expansion of red blood cell mass. The mechanism(s) underlying gestational changes of serum erythropoietin are unknown. Moreover, if erythropoietin synthesis increases, then the organ(s) questions about erythropoietin in pregnancy, we first set out to establish an animal model. Chronically instrumented, conscious unrestrained rats were studied. 51Cr-labeled red blood cells and radioimmunoassay were used to assess red blood cell mass and serum erythropoietin, respectively. Except for a lower hematocrit (P < 0.05 vs. virgin rats) and a slightly higher plasma volume (P value not significant) for gravid rats on gestational day 6, all other variables measured in early pregnancy rats were comparable to those measured in virgin control animals. Significant increases in total blood volume, plasma volume, and red blood cell mass were observed by gestational day 13 (midpregnancy) when compared with virgin control rats. These changes were even more pronounced on gestational day 20. Serum immunoreactive erythropoietin was also significantly increased at both of these stages of pregnancy. We conclude that the gravid rat is a reliable animal model of human gestation in which to further investigate erythropoietin in pregnancy.
G O Del Valle; M D Mosher; K P Conrad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  265     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-10-07     Completed Date:  1993-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R399-403     Citation Subset:  IM    
Department of Physiology, University of New Mexico School of Medicine, Albuquerque 87131.
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MeSH Terms
Analysis of Variance
Erythrocyte Volume*
Erythropoietin / blood*
Pregnancy, Animal / blood*
Rats, Inbred Strains
Regression Analysis
Time Factors
Reg. No./Substance:

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