Document Detail


Serum immunoreactive erythropoietin level: a new parameter for monitoring transfusion management of thalassaemia.
MedLine Citation:
PMID:  1780235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum immunoreactive erythropoietin (EPO) was measured sequentially in 8 patients with thalassaemia major. The EPO levels were distinctly increased before transfusion; they did not significantly change just after transfusion, but subsequently decreased. Pretransfusion EPO levels were similar to those observed in patients with non renal non inflammatory anaemias of the same severity. Our results show that production of EPO is appropriately increased in thalassaemia major and confirm that stimulation of endogenous erythropoiesis is not completely suppressed by the hypertransfusion regimen commonly used in this disease. As hyperstimulated ineffective erythropoiesis may lead to invalidating complications, we suggest that serum EPO measurements, which are now easily and reliably performed, should be used in monitoring the therapy of thalassaemia major.
Authors:
M André; P Bergmann; A Ferster; M Toppet; P Fondu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  33     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-10     Completed Date:  1992-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  IM    
Affiliation:
Laboratory of Haematology, Hôpital Brugmann, Brussels, B-Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood*
Blood Transfusion*
Child
Erythropoietin / blood*,  immunology
Female
Follow-Up Studies
Humans
Male
Thalassemia / blood*,  therapy
Chemical
Reg. No./Substance:
0/Biological Markers; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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