Document Detail

Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia.
MedLine Citation:
PMID:  24084059     Owner:  NLM     Status:  Publisher    
BACKGROUND: A population-based case-control study was designed to assess changes of serum levels of immunoglobulins and IgG subclasses between infected and convalescent phase in community-acquired pneumonia (CAP).
METHODS: Over a 2-year period, all subjects who were >14 years of age living in the Maresme region (Barcelona, Spain) diagnosed of CAP were registered. Controls were healthy subjects selected from the municipal census. Prognostic factors were assessed and serum levels of total IgG, IgA, IgM, and IgG subclasses were measured at diagnosis and 1 month later (cases).
RESULTS: We studied 171 patients with CAP and 90 controls. All immunoglobulins were significantly lower in cases than in controls. At diagnosis, 42.7% of cases showed low levels of some immunologic parameter, mainly total IgG and IgG2. Low immunoglobulin levels at diagnosis were more frequent in patients requiring in-patient care and in those with pneumonia of other etiology than Streptococcus pneumoniae. In the convalescent phase, 26 (23.6%) patients normalized immunological levels. In 27 (24.5%) cases, some parameter with low levels persisted especially in patients with etiology of CAP other than S. pneumoniae.
CONCLUSIONS: Low serum levels of immunoglobulins particularly total IgG and IgG2 were a common finding in patients with CAP compared to healthy controls. Low immunoglobulin levels may be related to CAP prognosis and persisted in the convalescent phase in one-fourth of cases.
Mari C de la Torre; Ignasi Bolíbar; Montse Vendrell; Javier de Gracia; Ester Vendrell; M José Rodrigo; Xavier Boquet; Pablo Torrebadella; Joan-Carles Yébenes; Mateu Serra-Prat; Jordi Rello; Antoni Torres; Jordi Almirall
Related Documents :
24240139 - A reliability study of colour-doppler sonography for the diagnosis of chronic cerebrosp...
24359249 - Characterization of seizure-induced syncopes: eeg, ecg, and clinical features.
23802939 - Utility of cystatin c for renal function in amyotrophic lateral sclerosis.
23815959 - Low-dose oral mini-pulse dexamethasone therapy in progressive unstable vitiligo.
25127049 - Obstructive sleep apnea and central serous chorioretinopathy.
22955689 - Elevated serum ykl-40 level predicts myocardial reperfusion and in-hospital mace in pat...
24240139 - A reliability study of colour-doppler sonography for the diagnosis of chronic cerebrosp...
21661419 - Does interleukin-18 play a role in the pathogenesis of hepatic encephalopathy?
1766079 - Clinical significance of junctional pacemaker automaticity in patients with sick sinus ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-18
Journal Detail:
Title:  Respiratory medicine     Volume:  -     ISSN:  1532-3064     ISO Abbreviation:  Respir Med     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Critical Care Service, Hospital de Mataró, Universitat Autònoma de Barcelona, CIBERES, Barcelona, Spain. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intentional Overdose With Tinzaparin: Management Dilemmas.
Next Document:  Evaluation of multidimensional COPD-related subjective fatigue following a Pulmonary Rehabilitation ...