Document Detail


Serum immunoglobulins and IgG subclasses in patients with glomerulonephritis.
MedLine Citation:
PMID:  2493066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The serum concentrations of IgG, IgA, IgM and of the four subclasses of IgG were determined by radial immunodiffusion in 103 patients, mean age 42 (range 16-72), with various types of glomerulonephritis. Forty-nine healthy blood donors, mean age 41 years (range 19-65), served as controls. Kidney biopsies were obtained from all the patients for examination by histopathology and by immunofluorescence. The glomerulopathies were classified according to WHO criteria. The serum immunoglobulin patterns were different for the various clinical groups of patients. Patients with Wegener's granulomatosis, rapidly progressive glomerulonephritis and SLE had a significant increase in total IgG and of IgG4 (P less than 0.05-0.001). Patients with minimal change disease had low concentrations of IgG (P less than 0.001) with a significant decrease in IgG1 and IgG2 (P less than 0.001 and 0.01, respectively). Highly significant increases in IgA were noted for patients with IgA nephritis (P less than 0.001) but high levels were also seen in patients with chronic glomerulonephritis. The findings might have diagnostic implications.
Authors:
G Almroth; P Sjöström; C Svalander; D Danielsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of internal medicine     Volume:  225     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-03-30     Completed Date:  1989-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Medical Centre Hospital, Orebro, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Female
Glomerulonephritis / immunology*,  pathology
Humans
Immunodiffusion
Immunoglobulin A / analysis
Immunoglobulin G / analysis*
Immunoglobulin M / analysis
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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