Document Detail

Serum immunoglobulin profiles of septicemic versus healthy neonates.
MedLine Citation:
PMID:  7748154     Owner:  NLM     Status:  MEDLINE    
We studied 125 clinically suspected septicemic neonates (Patient) aged from 1 to 28 days and 25 healthy neonates (control) of comparable age and sexes. Cultures of blood were done and serum immunoglobulins (IgG, IgA) were estimated in all the subjects. Blood cultures were found positive in 45 (36%) patients. Preterm patients showed significantly higher number of positive blood cultures as compared to term patients. The mean serum IgG level in patients was found significantly lower than that of the controls. The serum IgG levels were also found significantly lower in 75 preterm as compared to 50 term, and in 45 blood culture positive patients as compared to 80 blood culture negative patients. On the other hand, the mean serum IgM level in patients was found significantly higher as compared to controls. Similarly, serum IgM levels were found higher in preterm patients as compared to term patients and in blood culture positive patients as compared to blood culture negative patients. No significant difference of mean serum IgA level was found among the subjects. It is evident from our study, that blood culture positive patients were mostly preterm, in whom transplacental passage of IgG is insufficient and due to low IgG level, preterm baby cannot counteract bacterial invasion and as such, suffer from septicemia more frequently. Septicemic neonates as a rule showed higher level of serum IgM due to synthesis by themselves in primary response to infection.
I Ahmed; K M Rahman; R A Miah; T Hossain; S Khatoon; M Khatun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bangladesh Medical Research Council bulletin     Volume:  20     ISSN:  0377-9238     ISO Abbreviation:  Bangladesh Med Res Counc Bull     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-06-14     Completed Date:  1995-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607686     Medline TA:  Bangladesh Med Res Counc Bull     Country:  BANGLADESH    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM    
NIPSOM, Mohakhali, Dhaka.
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MeSH Terms
Immunoglobulins / analysis*
Infant, Newborn
Infant, Premature, Diseases / immunology
Sepsis / immunology*
Reg. No./Substance:

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