| Serum immunoglobulin free light chain measurements and heavy chain isotype usage provide insight into disease biology in patients with POEMS syndrome. | |
| | |
MedLine Citation:
|
PMID: 20513121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) syndrome is a rare paraneoplastic syndrome in which nearly all patients have a monoclonal lambda restricted plasma cell disorder. We investigated whether patients with POEMS have abnormal serum immunoglobulin free light chain (FLC) ratios. Fifty patients with newly diagnosed POEMS syndrome were assessed. Cystatin C levels were measured to discern whether subclinical renal insufficiency could account for FLC elevations in the presence of a normal FLC ratio. Forty-five patients (90%) had elevated lambda FLC; however, only nine (18%) had abnormal FLC ratios. The rise in serum FLC of POEMS patients appeared to be multifactorial-both a function of subclinical renal insufficiency and polyclonal activation of medullary and extramedullary plasma cells. Those patients expressing a clonal IgA were more likely to have clonal plasmacytosis observed on iliac crest biopsy than those with IgG. In summary, serum immunoglobulin profiles are unique in POEMS syndrome as compared with other plasma cell disorders. |
| | |
Authors:
|
Trista Stankowski-Drengler; Morie A Gertz; Jerry A Katzmann; Martha Q Lacy; Shaji Kumar; Nelson Leung; Suzanne R Hayman; Francis Buadi; Robert A Kyle; S Vincent Rajkumar; Angela Dispenzieri |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of hematology Volume: 85 ISSN: 1096-8652 ISO Abbreviation: Am. J. Hematol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-31 Completed Date: 2010-06-21 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
|
Languages: eng Pagination: 431-4 Citation Subset: IM |
Copyright Information:
|
2010 Wiley-Liss, Inc. |
Affiliation:
|
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Biopsy Clone Cells / pathology* Cystatin C / blood Female Gene Rearrangement, B-Lymphocyte, Heavy Chain* Humans Ilium / pathology Immunoglobulin A / blood* Immunoglobulin G / blood* Immunoglobulin Heavy Chains / blood* Immunoglobulin Light Chains / blood* Immunoglobulin lambda-Chains / blood Male Middle Aged POEMS Syndrome / blood*, immunology Plasma Cells / pathology* |
| Grant Support | |
ID/Acronym/Agency:
|
CA62242/CA/NCI NIH HHS; R01 CA125614-04/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/CST3 protein, human; 0/Cystatin C; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin Heavy Chains; 0/Immunoglobulin Light Chains; 0/Immunoglobulin lambda-Chains |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: C/EBPA gene mutation and C/EBPA promoter hypermethylation in acute myeloid leukemia with normal cyto...
Next Document: High incidence of false-positive Aspergillus galactomannan test in multiple myeloma.