Document Detail


Serum hyperglycosylated human chorionic gonadotropin to predict the gestational outcome in in vitro fertilization/intracytoplasmic sperm injection pregnancies.
MedLine Citation:
PMID:  18504387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted by the placenta in early pregnancy. Decreased H-hCG levels have been associated with abortion in spontaneous pregnancy. We retrospectively measured H-hCG and dimeric hCG in the sera of 87 in vitro fertilization patients obtained in the 3 weeks following embryo transfer and set the results in relation to pregnancy outcome. H-hCG and dimeric hCG were correlated (r(2) = 0.89), and were significantly decreased in biochemical pregnancy (2 microg/l and 18 IU/l, respectively) compared to early pregnancy loss (22 microg/l and 331 IU/l) and ongoing pregnancy (32 microg/l and 353 IU/l). Only H-hCG tended to discriminate between these last two groups.
Authors:
N A Bersinger; D M Wunder; M Nicolas; M H Birkhäuser; D Porquet; J Guibourdenche
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-05-27
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  24     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-16     Completed Date:  2008-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  74-8     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Affiliation:
Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland. nick.bersinger@dkf.unibe.ch
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MeSH Terms
Descriptor/Qualifier:
Chorionic Gonadotropin / blood*,  metabolism
Female
Fertilization in Vitro*
Glycosylation
Humans
Pregnancy
Pregnancy Outcome*
Pregnancy Tests / methods*
Retrospective Studies
Sperm Injections, Intracytoplasmic
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin

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