Document Detail

Serum hyaluronic acid as a comprehensive marker to assess severity of liver disease in schistosomiasis.
MedLine Citation:
PMID:  12429428     Owner:  NLM     Status:  MEDLINE    
Schistosomiasis mansoni is a non-cirrhotic fibrogenic disease model. The mild form shows normal liver function with slight or no liver fibrosis whereas in the periportal fibrosis form the manifestations of portal hypertension prevail over hepatocellular failure. We assessed serum hyaluronic acid as a marker of the course of the disease. We studied 24 patients presenting with pure chronic forms of schistosomiasis and seven with cirrhosis. In order to measure serum hyaluronic acid we developed a sandwich fluorescent ELISA-like assay. alpha2-Macroglobulin, prothrombin index, gamma-glutamyltransferase, platelets and ultrasound parameters were also assessed. The 20 micro g/l (ROC plot) hyaluronic acid level differentiated patients with the mild form (with no portal hypertension) from those with the severe form of schistosomiasis with 78% diagnostic efficacy. The 80 micro g/l cut-off value differentiated patients with the severe form of schistosomiasis from the cirrhotic group with similar diagnostic efficacy. alpha2-Macroglobulin provided no distinction between the groups studied. The hyaluronic acid serum concentration correlated positively with the splenic vein diameter (P=0.004) and marginally with alpha2-macroglobulin (P=0.059). Serum hyaluronic acid is a good marker for the initial phase of hepatic fibrosis and it was able to assess severity of liver disease in schistosomiasis.
L A Köpke-Aguiar; J R M Martins; C C Passerotti; C F Toledo; H B Nader; Durval R Borges
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta tropica     Volume:  84     ISSN:  0001-706X     ISO Abbreviation:  Acta Trop.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2002-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-26     Citation Subset:  IM    
Department of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.
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MeSH Terms
Biological Markers
Hyaluronic Acid / blood*
Liver Cirrhosis / blood*
Middle Aged
Schistosomiasis mansoni / blood*,  classification
Severity of Illness Index
alpha-Macroglobulins / metabolism
Reg. No./Substance:
0/Biological Markers; 0/alpha-Macroglobulins; 9004-61-9/Hyaluronic Acid

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