Document Detail


Serum hs-CRP was correlated with treatment response to pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.
MedLine Citation:
PMID:  21063486     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Serum high sensitivity C-reactive protein (hs-CRP) is a surrogate marker for cardiovascular disease risks and related mortality. However, the features of hs-CRP in chronic HCV infection (CHC) patients have not been fully addressed. This study aimed to elucidate the characteristics of hs-CRP and its correlation with clinical profiles in CHC patients.
METHODS: Ninety-five CHC patients and 95 age- and sex-matched healthy controls were enrolled for serum hs-CRP level, biochemical, and metabolic profiles examinations. Sequential changes of hs-CRP levels in CHC patients receiving peginterferon/ribavirin combination therapy were also evaluated.
RESULTS: The mean hs-CRP level of CHC patients was significantly higher than that of healthy controls (0.97 ± 0.11 vs. 0.24 ± 0.07 mg/L, P < 0.001). There was no significant correlation between hs-CRP and both virological and histological factors. CHC patients with a high LDL-C level had significantly higher mean hs-CRP (1.38 ± 0.20 mg/L) than that of patients without (0.59 ± 0.06 mg/L) (P < 0.001). Hs-CRP level was significantly decreased in 83 patients after peginterferon/ribavirin combination therapy (0.24 vs. 0.62 mg/L, P < 0.001), particularly in 68 patients achieving a sustained virological response (0.25 vs. 0.64 mg/L, P < 0.001).
CONCLUSION: CHC patients had a higher hs-CRP level than healthy controls which could be ameliorated after peginterferon/ribavirin combination therapy.
Authors:
Chung-Feng Huang; Ming-Yen Hsieh; Jeng-Fu Yang; Wu-Cheng Chen; Ming-Lun Yeh; Ching-I Huang; Chia-Yen Dai; Ming-Lung Yu; Zu-Yau Lin; Shinn-Chern Chen; Wan-Long Chuang; Jee-Fu Huang
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Publication Detail:
Type:  Journal Article     Date:  2010-08-04
Journal Detail:
Title:  Hepatology international     Volume:  4     ISSN:  1936-0541     ISO Abbreviation:  Hepatol Int     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-10     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101304009     Medline TA:  Hepatol Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  621-7     Citation Subset:  -    
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