Document Detail

Serum homovanillic acid levels in schizophrenic patients and normal control subjects.
MedLine Citation:
PMID:  8416025     Owner:  NLM     Status:  MEDLINE    
Schizophrenic patients with an early age at onset of illness had low baseline levels of homovanillic acid (HVA) in serum compared with schizophrenic patients with a late age at onset. After adjustments were made for age at onset, there was a significant partial correlation between positive symptoms and serum HVA. The relationship between positive symptom scores and serum HVA was shifted to the left in the early onset patients, suggesting a relatively increased sensitivity of dopamine-associated response. Patients with severe negative symptoms also had an earlier age at onset and a trend toward lower serum HVA. This study found no difference between mean serum HVA values in schizophrenic patients and normal control subjects.
J L Steinberg; D L Garver; F G Moeller; J D Raese; P J Orsulak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  48     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-23     Completed Date:  1993-11-23     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  93-106     Citation Subset:  IM    
Department of Veterans Affairs Medical Center, Dallas, TX.
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MeSH Terms
Homovanillic Acid / blood*
Psychiatric Status Rating Scales
Reference Values
Schizophrenia / blood*
Schizophrenic Psychology*
Reg. No./Substance:
306-08-1/Homovanillic Acid

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