| Serum homocysteine and physical exercise in patients with Parkinson's disease. | |
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MedLine Citation:
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PMID: 21707858 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Hyperhomocysteinemia is a major risk factor for cerebral and peripheral vascular diseases, as well as cortical and hippocampal injury, including an increased risk of dementia and cognitive impairment. Elevated serum homocysteine (Hcy) concentrations are common in patients with Parkinson's disease (PD) who have been treated with levodopa; however, physical exercises can help reduce Hcy concentrations. The aim of the present study was to compare serum Hcy levels in patients with PD who partook in regular physical exercises, sedentary PD patients, and healthy controls. Methods: Sixty individuals were enrolled in the present study across three groups: (i) 17 patients who did not partake of any type of exercise; (ii) 24 PD patients who exercised regularly; and (iii) 19 healthy individuals who did not exercise regularly. All participants were evaluated by Hoehn and Yahr scale, the Unified Parkinson's Disease Rating Scale (UPDRS) and Schwab and England scale (measure daily functionality). The serum levels of Hcy were analyzed by blood samples collected of each participant. An analysis of variance and a Tukey's post hoc test were applied to compare and to verify differences between groups. Pearson's correlation and stepwise multiple regression analyses were used to consider the association between several variables. Results: Mean plasma Hcy concentrations in individuals who exercised regularly were similar to those in the healthy controls and significantly lower than those in the group that did not exercise at all (P= 0.000). In addition, patients who did not exercise were receiving significantly higher doses of levodopa than those patients who exercised regularly (P= 0.001). A positive relationship between levodopa dose and Hcy concentrations (R(2) = 0.27; P= 0.03) was observed in patients who did not exercise, but not in those patients who exercised regularly (R(2) = 0.023; P= 0.15). Conclusions: The results of the present study suggest that, even with regular levodopa therapy, Hcy concentrations in PD patients who exercise regularly are significantly lower than in patients who do not exercise and are similar Hcy concentrations in healthy controls. |
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Authors:
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Carla Manuela Crispim Nascimento; Florindo Stella; Célia Regina Garlipp; Ruth Ferreira Santos; Sebastião Gobbi; Lilian Teresa Bucken Gobbi |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society Volume: 11 ISSN: 1479-8301 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230058 Medline TA: Psychogeriatrics Country: - |
Other Details:
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Languages: ENG Pagination: 105-112 Citation Subset: - |
Copyright Information:
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© 2011 The Authors; Psychogeriatrics © 2011 Japanese Psychogeriatric Society. |
Affiliation:
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Laboratory of Aging and Physical Activity (LAFE), Biosciences Institute, Department of Physical Education, São Paulo State University, Rio Claro Campus, Brazil Clinical Geriatric Psychiatry, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil Clinical Pathology Laboratory, Faculty of Medical Sciences, State University of Campinas, Campinas Mathematics, Computation and Cognition Center, Cognition and Complex Systems Nucleus, Federal University of ABC, São Paulo, Brazil Laboratory of Posture and Locomotion Study (LEPLO), Biosciences Institute, Department of Physical Education, São Paulo State University, Rio Claro Campus. |
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