| Serum hippurate and its excretion in conservatively treated and dialysed patients with chronic renal failure. | |
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MedLine Citation:
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PMID: 1811729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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54 healthy volunteers or patients with normal kidney and liver function, 17 patients with decreased kidney function and 12 dialysed patients were evaluated for their serum hippurate accumulation and kidney excretion. It was found that there was an inverse relationship between serum hippurate and the clearance of endogenous creatinine (CCr) and a free relationship between fractional excretion of hippurate and CCr. The excretory capacity in residual nephrons was increased. This was caused by the greater glomerular filtration load which increased up to 25 times and tubular secretion which increased 7 times in dialysed patients. The relative contribution of glomerular filtration to hippurate excretion rose from about 20% in controls to almost 50% in dialysed patients. True kidney adaptation was localized in the organic anion transport system of proximal tubules. |
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Authors:
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V Spustová; M Gajdos; K Opatrný; K Stefíková; R Dzúrik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 40 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 1991 |
Date Detail:
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Created Date: 1992-06-10 Completed Date: 1992-06-10 Revised Date: 2008-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 599-606 Citation Subset: IM |
Affiliation:
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Centre of Clinical Pharmacology, Institute of Preventive and Clinical Medicine, Bratislava. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Hippurates
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blood*,
urine Humans Kidney Failure, Chronic / blood*, therapy, urine Osmolar Concentration Reference Values Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Hippurates; 495-69-2/hippuric acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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