| Serum high-sensitivity C-reactive protein, amyloidassociated protein and N-terminal proBNP levels do not predict reversible myocardial ischaemia. | |
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MedLine Citation:
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PMID: 21556451 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: The aim of this study was to detect any relationship between serum high-sensitivity C-reactive protein (hs-CRP), serum amyloid-associated protein (SAA) and N-terminal pro B-type natriuretic peptide (NT-proBNP) levels, and reversible myocardial ischaemia during cardiovascular exercise tests and to determine whether these biomarkers could predict transient myocardial ischaemia. METHODS: Ninety-six patients (36 women, 60 men, mean age 57 ± 8.5 years) were included in the study. Venous blood samples were taken from patients before and 15 minutes after exercise testing. SAA and hs-CRP were analysed using immunonephelometric assays (Dade-Behring, BN II, Marburg, Germany). NT-proBNP (pg/ml) was determined using the immulite 1 000 chemiluminescence immunoassay system (Siemens Medical Solution Diagnostics, Deerfiled, USA). Forty-eight patients (18 women, 30 men) with positive exercise tests were allocated to the exercise-positive group and 48 (18 women, 30 men) with negative exercise tests were put in the exercise-negative group. Coronary angiography was performed on all patients in the exercise-positive group. RESULTS: There was no difference between the levels of hs-CRP, SAA and NT-pro-BNP before and after exercise testing in both of the exercise groups. CONCLUSION: Serum levels of hs-CRP, SAA and NT-proBNP could not predict the occurrence of reversible myocardial ischaemia during exercise. Large-scale clinical studies are needed to clarify the status of hs-CRP, SAA and NT-proBNP with exercise. |
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Authors:
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M Başkurt; F Aktürk; K Keskin; P Canbolat; B Karadag; A Kaya; A Yildiz; U Coskun; K Kilickesmez; O Esen; S K Muniboglu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular journal of Africa Volume: 22 ISSN: 1995-1892 ISO Abbreviation: Cardiovasc J Afr Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-05-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101313864 Medline TA: Cardiovasc J Afr Country: South Africa |
Other Details:
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Languages: eng Pagination: 85-9 Citation Subset: IM |
Affiliation:
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Cardiology Department, Institute of Cardiology, Istanbul University, Haseki, Istanbul. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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