| Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women. | |
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MedLine Citation:
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PMID: 19073788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hepcidin is a key regulator of iron homeostasis, but to date no studies have examined the effect of hepcidin on iron absorption in humans. OBJECTIVE: Our objective was to assess relations between both serum hepcidin and serum prohepcidin with nonheme-iron absorption in the presence and absence of food with the use of dual stable-iron-isotope techniques. DESIGN: The study group included 18 healthy nonpregnant women. Women received in random order a supplemental iron source (7.6 mg FeSO4 providing 0.9 mg 58Fe as FeSO4) and 6.8 mg 57Fe ferrous sulfate tracer administered with a nonheme food source [orange-fleshed sweet potato (OFSP): 1.4 mg native Fe]. Iron absorption was determined by analyzing blood samples taken 14 d after dosing with the use of magnetic sector thermal ionization mass spectrometry. Serum hepcidin was assessed by a new competitive serum enzyme-linked immunosorbent assay (ELISA) specific for the refolded, mature 25-amino acid form, and serum prohepcidin was assessed by an ELISA specific for amino acids 28-47 of the hepcidin prohormone. RESULTS: In these women, iron absorption averaged 14.71 +/- 10.7% from the supplemental iron compared with 3.63 +/- 6.5% from the OFSP. Absorption of nonheme iron assessed in the presence (P = 0.038) and absence (P = 0.0296) of food was significantly associated with serum hepcidin but was not significantly related to serum prohepcidin. CONCLUSION: Serum hepcidin, but not prohepcidin, was inversely associated with iron absorption from supplemental and food-based nonheme-iron sources in iron-replete healthy women. |
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Authors:
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Melissa F Young; Raymond P Glahn; Magnolia Ariza-Nieto; Jeremy Inglis; Gordana Olbina; Mark Westerman; Kimberly O O'Brien |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-12-10 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 89 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-02-11 Revised Date: 2009-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 533-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antimicrobial Cationic Peptides / blood*, pharmacology Biological Availability Dietary Supplements* Enzyme-Linked Immunosorbent Assay Female Ferritins / blood Hemoglobins / analysis Humans Intestinal Absorption / drug effects* Ipomoea batatas / chemistry Iron Compounds / blood, metabolism, pharmacokinetics Iron Isotopes Iron, Dietary / blood, metabolism, pharmacokinetics* Mass Spectrometry Nutritional Status Premenopause Protein Precursors / blood*, pharmacology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antimicrobial Cationic Peptides; 0/Hemoglobins; 0/Iron Compounds; 0/Iron Isotopes; 0/Iron, Dietary; 0/Protein Precursors; 0/hepcidin; 0/prohepcidin; 9007-73-2/Ferritins |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2009 Feb;89(2):475-6
[PMID:
19088153
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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