Document Detail

Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women.
MedLine Citation:
PMID:  19073788     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hepcidin is a key regulator of iron homeostasis, but to date no studies have examined the effect of hepcidin on iron absorption in humans. OBJECTIVE: Our objective was to assess relations between both serum hepcidin and serum prohepcidin with nonheme-iron absorption in the presence and absence of food with the use of dual stable-iron-isotope techniques. DESIGN: The study group included 18 healthy nonpregnant women. Women received in random order a supplemental iron source (7.6 mg FeSO4 providing 0.9 mg 58Fe as FeSO4) and 6.8 mg 57Fe ferrous sulfate tracer administered with a nonheme food source [orange-fleshed sweet potato (OFSP): 1.4 mg native Fe]. Iron absorption was determined by analyzing blood samples taken 14 d after dosing with the use of magnetic sector thermal ionization mass spectrometry. Serum hepcidin was assessed by a new competitive serum enzyme-linked immunosorbent assay (ELISA) specific for the refolded, mature 25-amino acid form, and serum prohepcidin was assessed by an ELISA specific for amino acids 28-47 of the hepcidin prohormone. RESULTS: In these women, iron absorption averaged 14.71 +/- 10.7% from the supplemental iron compared with 3.63 +/- 6.5% from the OFSP. Absorption of nonheme iron assessed in the presence (P = 0.038) and absence (P = 0.0296) of food was significantly associated with serum hepcidin but was not significantly related to serum prohepcidin. CONCLUSION: Serum hepcidin, but not prohepcidin, was inversely associated with iron absorption from supplemental and food-based nonheme-iron sources in iron-replete healthy women.
Melissa F Young; Raymond P Glahn; Magnolia Ariza-Nieto; Jeremy Inglis; Gordana Olbina; Mark Westerman; Kimberly O O'Brien
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-12-10
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  89     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-02-11     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-8     Citation Subset:  AIM; IM    
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA.
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MeSH Terms
Antimicrobial Cationic Peptides / blood*,  pharmacology
Biological Availability
Dietary Supplements*
Enzyme-Linked Immunosorbent Assay
Ferritins / blood
Hemoglobins / analysis
Intestinal Absorption / drug effects*
Ipomoea batatas / chemistry
Iron Compounds / blood,  metabolism,  pharmacokinetics
Iron Isotopes
Iron, Dietary / blood,  metabolism,  pharmacokinetics*
Mass Spectrometry
Nutritional Status
Protein Precursors / blood*,  pharmacology
Young Adult
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Hemoglobins; 0/Iron Compounds; 0/Iron Isotopes; 0/Iron, Dietary; 0/Protein Precursors; 0/hepcidin; 0/prohepcidin; 9007-73-2/Ferritins
Comment In:
Am J Clin Nutr. 2009 Feb;89(2):475-6   [PMID:  19088153 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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