| Serum hepcidin-25 levels predict the progression of renal anemia in patients with non-dialysis chronic kidney disease. | |
| | |
MedLine Citation:
|
PMID: 22833619 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BackgroundHepcidin is associated with iron-restricted erythropoiesis. A previous cross-sectional study showed that serum hepcidin-25 levels are negatively associated with the hemoglobin concentration in non-dialysis chronic kidney disease (CKD) patients with sufficient iron stores. This longitudinal study aimed at ascertaining the association between hepcidin-25 levels and the progression of renal anemia.MethodsWe selected 335 non-dialysis CKD patients who showed hemoglobin concentrations >10 g/dL and who were not receiving erythropoiesis-stimulating agent (ESA) therapy, from among the subjects of our previous study, who had been recruited between February and June 2007 in a previous study. The primary outcome was the start of the ESA therapy or hemoglobin concentrations remaining below 10 g/dL for >3 months, by 31 December 2010. The patients were classified into high- and low-ferritin groups depending on their median ferritin levels. The Cox proportional hazard model with restricted cubic spline curve analysis was used to determine the association between hepcidin-25 levels and the outcome for each group.ResultsThe hepcidin-25 level was a significant predictor both for the high-ferritin group (P = 0.04, linearity = 0.02) and for the low-ferritin group (P = 0.04, linearity P = 0.02). The spline curve for the high-ferritin group showed that higher hepcidin-25 levels had a high log-relative hazard.ConclusionsHigher hepcidin-25 levels predict the progression of anemia in non-dialysis CKD patients with sufficient iron stores, indicating the involvement of hepcidin in the progression of anemia in non-dialysis CKD patients. |
| | |
Authors:
|
Kakuya Niihata; Naohisa Tomosugi; Takuya Uehata; Tatsuya Shoji; Kensuke Mitsumoto; Morihiro Shimizu; Hiroaki Kawabata; Yusuke Sakaguchi; Akira Suzuki; Terumasa Hayashi; Noriyuki Okada; Yoshitaka Isaka; Hiromi Rakugi; Yoshiharu Tsubakihara |
Related Documents
:
|
1988269 - Prospective study on prevalence of esophageal chest pain in patients referred on an ele... 8514059 - Endoluminal ultrasonography of the distal esophagus in systemic sclerosis. 2011159 - Dysphagia in patients with the post-polio syndrome. 3718219 - Radionuclide esophageal transit. a screening test for esophageal disorders. 4951149 - Does a sliding hiatus hernia constitute a distinct clinical entity? 6832529 - Reflux esophagitis: radiologic-endoscopic correlation in 39 symptomatic cases. 19920719 - A comparison of migraine patients with and without allodynic symptoms. 9873839 - Urinary n-acetyl-beta-d-glucosaminidase in rheumatoid arthritis. 1931779 - Reoperation after cholecystectomy. the role of the cystic duct stump. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-24 |
Journal Detail:
|
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: - ISSN: 1460-2385 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Department of Kidney Disease and Hypertension, Osaka General Medical Center, Osaka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Screening for colorectal cancer and advanced colorectal neoplasia in kidney transplant recipients: c...
Next Document: Instrumental variable analysis.