Document Detail

Serum heme oxygenase-1 levels are increased in Parkinson's disease but not in Alzheimer's disease.
MedLine Citation:
PMID:  19785642     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Oxidative stress is implicated in Parkinson's disease (PD) and Alzheimer's disease (AD), and heme oxygenase-1 (HO-1) is a potent antioxidant overexpressed in PD substantia nigra and AD cerebral cortex and hippocampus, indicating a possible up-regulation of antioxidant defenses in both neurodegenerative diseases. The role of HO-1 in peripheral blood of PD and AD patients remains unresolved. METHODS: We measured serum HO-1 levels in 107 patients with PD, 105 patients with AD, 104 controls for PD and 120 controls for AD. RESULTS: The median serum concentration of HO-1 was significantly higher in PD patients (2.04 ng/ml) compared with that of PD controls (1.69 ng/ml, P = 0.016), with PD patients predominating over controls in the upper tertile of serum HO-1 levels, whereas there was more PD controls than PD patients in the lower tertile (P = 0.006). Median serum levels of HO-1 did not differ significantly between AD patients and AD controls. CONCLUSION: The increase of serum HO-1 levels in PD patients could indicate a systemic antioxidant reaction related to a chronic oxidative stress state in PD brain.
I Mateo; J Infante; P S?nchez-Juan; I Garc?a-Gorostiaga; E Rodr?guez-Rodr?guez; J L V?zquez-Higuera; J Berciano; O Combarros
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-24
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  121     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  136-8     Citation Subset:  IM    
Neurology Service and Centro de Investigaci?n Biom?dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Marqu?s de Valdecilla University Hospital (University of Cantabria), Santander, Spain.
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MeSH Terms
Age Factors
Aged, 80 and over
Alzheimer Disease / blood*,  drug therapy,  genetics
Apolipoprotein E4 / genetics
Heme Oxygenase-1 / blood*
Middle Aged
Parkinson Disease / blood*,  drug therapy
Severity of Illness Index
Sex Factors
Time Factors
Reg. No./Substance:
0/Apolipoprotein E4; EC Oxygenase-1

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