Document Detail

Serum guanidino compound levels in uremic pediatric patients treated with hemodialysis or continuous cycle peritoneal dialysis. Correlations between nerve conduction velocities and altered guanidino compound concentrations.
MedLine Citation:
PMID:  7777105     Owner:  NLM     Status:  MEDLINE    
Serum levels of twelve guanidino compounds (GCs) and nerve conduction velocities were determined in a dialyzed renal insufficient pediatric population. Two dialytic groups were considered: one subjected to hemodialysis (HD, 11 patients) and one subjected to continuous cycle peritoneal dialysis (CCPD, 13 patients). Before HD, marked increases were found for guanidino-succinic acid (207 times), methylguanidine (> or = 67 times), argininic acid (24 times), creatinine and alpha-N-acetylarginine (18 times) and guanidine (> or = 14 times) when compared to controls. Important significant increases were still present after an HD session for guanidinosuccinic acid (49 times), methylguanidine (34 times), creatinine (7 times) and alpha-N-acetylarginine and guanidine (6 times). After HD, creatine, arginine and homoarginine were lower than in controls. All GCs, with the exception of creatine, decreased significantly after a single HD session with percentage decrease ranging between 40% (for arginine) and 77% (for guanidinosuccinic acid). Creatine decreased in a statistically nonsignificant manner by 48%. Marked increases were found in the CCPD group for guanidinosuccinic acid (114 times), alpha-N-acetylarginine (12 times), argininic acid (15 times), creatinine (22 times), guanidine (> or = 11 times) and methylguanidine (> or = 48 times). Concentrations of guanidinosuccinic acid before and after HD and in CCPD were comparable to those reported to be toxic in vitro and in vivo. No clinical or electrophysiological indications of polyneuropathy were observed in our population. Sensory and motor nerve conduction studies showed few abnormalities apart from a significant correlation between argininic acid concentration or guanidine levels and the peroneal nerve conduction velocity in the CCPD-treated group.
P P De Deyn; P Robitaille; M Vanasse; I A Qureshi; B Marescau
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  69     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1995  
Date Detail:
Created Date:  1995-07-12     Completed Date:  1995-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  IM    
Laboratory of Neurochemistry and Behavior, A.Z. Middelheim, Born-Bunge Foundation, University of Antwerp, Belgium.
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MeSH Terms
Arginine / analogs & derivatives,  blood
Child, Preschool
Creatinine / blood
Guanidines / blood*
Methylguanidine / blood
Neural Conduction / physiology
Peritoneal Dialysis*
Renal Dialysis*
Succinates / blood
Urea / blood
Uremia / blood*,  physiopathology,  therapy*
Reg. No./Substance:
0/Guanidines; 0/Succinates; 113-00-8/Guanidine; 155-84-0/N-acetyl-L-arginine; 157-07-3/argininic acid; 471-29-4/Methylguanidine; 57-13-6/Urea; 60-27-5/Creatinine; 6133-30-8/guanidinosuccinic acid; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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