| Serum growth factors in hemodialyzed patients. | |
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MedLine Citation:
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PMID: 15046632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The contact of chronic hemodialysis patients' blood with components of extracorporeal circulation leads to mobilization of several systemic reactions. The purpose of this study was to determine the activity of transforming growth factor (TGF-beta1) and platelet derived growth factor (PDGF) in serum of patients on long-term hemodialysis program and to compare these results with ones obtained in healthy volunteers. Twenty-five patients on dialysis carried out on polysulfone membrane dialyzer, and 16 patients on dialysis with the used of cuprophan membrane dialyzer on long-term hemodialysis program participated in the study. TGF-beta1 level in serum of healthy volunteers (12.06 +/- 7.56 ng/mL) was lower than in serum of patients dialyzed on polysulfone membrane dialyzers (26.56 +/- 14.83 ng/mL). Differences in PDGF concentrations in serum of control group and hemodialyzed patients were not statistically significant. The strong correlation between TGF-beta1 and PDGF in serum of both studied groups of patients was demonstrated. |
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Authors:
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Leszek Paczek; Małgorzata Gomółka; Stanisław Niemczyk; Irena Bartłomiejczyk; Dorota Gerwatowska; Katerina Sebekova; August Heidland |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Artificial organs Volume: 28 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-29 Completed Date: 2004-07-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 314-6 Citation Subset: IM |
Affiliation:
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Transplantation Institute, Warsaw School of Medicine, Warsaw, Poland. lpaczek@ikp.atm.com.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Kidney Failure, Chronic / therapy Male Membranes, Artificial* Middle Aged Platelet-Derived Growth Factor / analysis, biosynthesis* Renal Dialysis / methods* Transforming Growth Factor beta / biosynthesis*, blood Transforming Growth Factor beta1 |
| Chemical | |
Reg. No./Substance:
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0/Membranes, Artificial; 0/Platelet-Derived Growth Factor; 0/TGFB1 protein, human; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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