Document Detail


Serum glycoproteins and severity of coronary atherosclerosis.
MedLine Citation:
PMID:  7832094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relation of serum glycoproteins and C-reactive protein (CRP) to severity of coronary atherosclerosis was examined in 133 men and 92 women undergoing coronary angiography. The following serum glycoproteins were determined: alpha 1-antitrypsin, alpha 1-acid glycoprotein, alpha 2-macroglobulin, ceruloplasmin, haptoglobin, fibrinogen, C4b binding protein, and lipoprotein (a) [Lp(a)]. Sex- and age-adjusted levels of alpha 1-antitrypsin, alpha 1-acid glycoproteins, alpha 2-macroglobulin, ceruloplasmin, Lp(a) and CRP were significantly associated with the severity of coronary atherosclerosis as determined by the Gensini score; these associations remained significant even after adjustment for body-mass index, smoking history, hypertension, and total cholesterol, except for Lp(a) (p = 0.075). These findings suggest that certain serum glycoproteins and CRP can serve as independent indicators for the progression of coronary atherosclerosis.
Authors:
T Mori; J Sasaki; H Kawaguchi; K Handa; Y Takada; A Matsunaga; S Kono; K Arakawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  129     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-02-22     Completed Date:  1995-02-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  234-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Fukuoka University Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / blood
Biological Markers / blood
Body Mass Index
C-Reactive Protein / analysis
Coronary Angiography
Coronary Artery Disease / blood*,  radiography
Fasting / blood
Female
Glycoproteins / blood*
Humans
Male
Middle Aged
Severity of Illness Index
Sex Characteristics
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Glycoproteins; 9007-41-4/C-Reactive Protein

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