Document Detail

Serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase activity in premature and full-term asphyxiated newborns.
MedLine Citation:
PMID:  3978157     Owner:  NLM     Status:  MEDLINE    
The serum activity of SGOT and SGPT is one of the more specific parameters of liver cell injury both in adults and in the pediatric age-group. The determination of serum transaminase activity could offer a routine and rapid laboratory test for establishing the presence of hepatic cellular damage following intrauterine or perinatal asphyxia. In fact, it appears that there is a correlation between hypoxia and the increase in serum activity of transaminases in full-term and premature asphyxiated newborns. However, this increase is reversible up to the 30th day of life. The behavior of transaminase enzymatic activity in premature asphyxiated newborns compared to full-term asphyxiated newborns suggests a higher resistance of membranes to hypoxic-ischemic injuries and a lower enzymatic pool of cellular metabolism in premature newborns. Therefore, knowledge of the behavior of SGOT and SGPT activity may have important implications in the diagnosis and early treatment of perinatal asphyxia.
V Zanardo; M Bondio; G Perini; G F Temporin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  47     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1985  
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  61-9     Citation Subset:  IM    
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MeSH Terms
Alanine Transaminase / blood*
Aspartate Aminotransferases / blood*
Asphyxia Neonatorum / blood*,  enzymology
Infant, Newborn
Infant, Premature*
Reg. No./Substance:
EC Aminotransferases; EC Transaminase

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