Document Detail

Serum ghrelin concentration and weight gain in healthy term infants in the first year of life.
MedLine Citation:
PMID:  16254526     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Ghrelin, a recently discovered hormone mainly secreted by the stomach, has several metabolic functions including regulation of food intake, energy homeostasis and body weight. There are few studies on this hormone in healthy infants during the first year of life. The aim of this study was to examine the correlations between ghrelin and weight gain in healthy term infants in the first year of life. METHODS: 104 healthy term infants aged 0 to 12 months were included in a cross-sectional study. Anthropometric measurements were assessed and mean weight gain was calculated. Serum ghrelin concentrations have been determined at least 3 hours after feeding by radioimmunoassay test. RESULTS: Ghrelin concentrations were correlated negatively to weight gain (r=-0.302; P=0.003) and positively to age (r = 0.412; P < 0.001), weight (r = 0.374; P < 0.001) and length (r=0.387; P<0.001). In breastfed infants a statistically significant negative correlation between ghrelin concentration and infant weight gain (r=-0.407; P=0.001) was observed, whereas in formula-fed infants this correlation was not statistically significant (r=-0.067; P=0.719). CONCLUSIONS: The negative correlation observed between ghrelin concentration and infant weight gain suggests that ghrelin might also play a role in the regulation of body weight in healthy infants with a physiologic energy balance. Further studies are needed to clarify how ghrelin might be involved in both short-term and long-term energy balance.
F Savino; S A Liguori; M F Fissore; R Oggero; L Silvestro; R Miniero
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  41     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-28     Completed Date:  2006-04-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  653-9     Citation Subset:  IM    
Department of Pediatrics, Ospedale Infantile Regina Margherita University of Turin, Torino, Italy.
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MeSH Terms
Age Factors
Body Height / physiology
Breast Feeding*
Cross-Sectional Studies
Infant Formula*
Infant, Newborn / blood,  growth & development*
Peptide Hormones / blood*
Weight Gain / physiology*
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones
Comment In:
J Pediatr Gastroenterol Nutr. 2005 Nov;41(5):575-7   [PMID:  16254512 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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