Document Detail


Serum gamma-glutamyltransferase fractions in myotonic dystrophy type I: differences with healthy subjects and patients with liver disease.
MedLine Citation:
PMID:  20691173     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Elevation of serum gamma-glutamyltransferase (GGT), in absence of a clinically significant liver damage, is often found in Myotonic Dystrophy type-1 (DM1). In this study we investigated if a specific GGT fraction pattern is present in DM1.
DESIGNS AND METHODS: We compared total and fractional GGT values (b-, m-, s-, f-GGT) among patients with DM1 or liver disease (LD) and healthy subjects (HS).
RESULTS: The increase of GGT in DM1 and LD, vs HS, was mainly due to s-GGT (median: 32.7; 66.7; and 7.9 U/L, respectively), and b-GGT (8.5; 18.9; and 2.1 U/L). The subset of DM1 patients matched with HS with corresponding serum GGT showed higher b-GGT (6.0 vs 4.2 U/L).
CONCLUSIONS: DM1 patients with normal total GGT values showed an alteration of the production and release in the blood of GGT fractions. Since increased s-GGT is also found in LD, a sub-clinical liver damage likely occurs in DM1 subjects apparently free of liver disease.
Authors:
Maria Franzini; Irene Fornaciari; Gabriele Siciliano; Leda Volpi; Giulia Ricci; Santino Marchi; Giuseppina Gagliardi; Angelo Baggiani; Francesca Torracca; Vanna Fierabracci; Mario Miccoli; Alfonso Pompella; Michele Emdin; Aldo Paolicchi
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Publication Detail:
Type:  Journal Article     Date:  2010-08-04
Journal Detail:
Title:  Clinical biochemistry     Volume:  43     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1246-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Affiliation:
Scuola Superiore S. Anna, Pisa, Italy. m.franzini@sssup.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Chemical Fractionation
Female
Health*
Humans
Liver Diseases / blood*,  enzymology*
Male
Middle Aged
Myotonic Dystrophy / blood*,  enzymology*
gamma-Glutamyltransferase / blood*
Chemical
Reg. No./Substance:
EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.3.2.2/gamma-glutamyltransferase, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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