Document Detail


Serum gamma-glutamyltransferase is associated with arterial stiffness in healthy individuals.
MedLine Citation:
PMID:  21521327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Gamma-glutamyltransferase (GGT) has been reported to be useful in predicting cardiovascular disease. Arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) is not only a marker of vascular damage but a significant predictor of cardiovascular events. Gender difference has been reported in the association between GGT and baPWV. We assessed, therefore, the association between GGT and baPWV in a large population and determined whether there was gender difference.
DESIGN: This cross-sectional study was conducted at the Asan Medical Centre, Seoul, Republic of Korea.
SUBJECTS AND MEASUREMENTS: Serum GGT, baPWV and conventional risk factors were measured in 10 988 apparently healthy subjects (7248 men, 3740 women) who participated in a routine health screening examination.
RESULTS: In both men and women, we observed positive linearity between GGT quartiles and body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides, uric acid, high-sensitive C-reactive protein (hsCRP) and homeostatic model assessment of insulin resistance (HOMA-IR) score (P for trends < 0·001). The proportion of individuals with diabetes, hypertension increased as the GGT quartile increased (P for trends < 0·001). Age-adjusted mean baPWV increased gradually in both males and females according to GGT quartiles (P for trends < 0·001 in both genders). The odds for higher baPWV (i.e. >75th percentile in each sex) were significantly higher in the highest compared with the lowest GGT quartiles, after adjustment for confounding variables, in both men [odds ratio (OR) = 1·63, 95% CI = 1·21-2·20] and women (OR = 1·56, 95% CI = 1·08-2·27).
CONCLUSIONS: These results suggest that GGT is independently associated with the increased level of arterial stiffness both in men and in women and the association between them appears to be stronger in men compared to women.
Authors:
Chang Hee Jung; Ji Hee Yu; Sung Jin Bae; Eun Hee Koh; Min-Seon Kim; Joong-Yeol Park; Hong-Kyu Kim; Woo Je Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  75     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-05     Completed Date:  2012-01-25     Revised Date:  2012-03-05    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  328-34     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Ankle Brachial Index
Blood Glucose / analysis
Blood Pressure / physiology
Body Mass Index
C-Reactive Protein / analysis
Cardiovascular Diseases / blood*,  diagnosis,  physiopathology*
Cholesterol / blood
Cholesterol, LDL / blood
Cross-Sectional Studies
Female
Humans
Insulin Resistance
Logistic Models
Male
Mass Screening / methods
Middle Aged
Multivariate Analysis
Pulsatile Flow
Sex Factors
Triglycerides / blood
Uric Acid / blood
Vascular Stiffness / physiology*
Waist Circumference / physiology
gamma-Glutamyltransferase / blood*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, LDL; 0/Triglycerides; 57-88-5/Cholesterol; 69-93-2/Uric Acid; 9007-41-4/C-Reactive Protein; EC 2.3.2.2/gamma-Glutamyltransferase
Comments/Corrections
Comment In:
Clin Endocrinol (Oxf). 2011 Dec;75(6):865-6   [PMID:  21554374 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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