Document Detail

Serum fructosamine and amniotic fluid insulin levels in patients with gestational diabetes and healthy control subjects.
MedLine Citation:
PMID:  2187348     Owner:  NLM     Status:  MEDLINE    
Gestational diabetic pregnancies with fetal hyperinsulinism should be identified because these cases require insulin therapy. To determine the relationship between the serum fructosamine and amniotic fluid insulin concentrations, these substances were measured in 87 pregnant women with impaired glucose tolerance. Fructosamine was also measured in 678 healthy pregnant control subjects, in 113 of whom amniotic fluid insulin levels were available. Fetal hyperinsulinism was rare at serum fructosamine levels of less than 2.6 mmol/L. These results suggest that when both the oral glucose tolerance test and fructosamine level are used, only 30% of women with gestational diabetes need to undergo amniocentesis to assess fetal insulin homeostasis.
H M Hofmann; P A Weiss; P Pürstner; J Haas; G Gmoser; K Tamussino; B Schmon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  162     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-15     Completed Date:  1990-06-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1174-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Graz, Austria.
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MeSH Terms
Amniotic Fluid / metabolism*
Fetal Diseases / diagnosis
Glucose Tolerance Test
Hexosamines / blood*
Hyperinsulinism / diagnosis
Insulin / metabolism*,  therapeutic use
Pregnancy / blood,  metabolism*
Pregnancy in Diabetics / blood,  metabolism*,  therapy
Reg. No./Substance:
0/Hexosamines; 11061-68-0/Insulin; 4429-04-3/Fructosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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