Document Detail

Serum free thyroxine concentration is not reduced in premature infants with respiratory distress syndrome.
MedLine Citation:
PMID:  9329438     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We used improved methods of assay to determine whether pituitary-thyroid function is altered in premature infants with respiratory distress syndrome (RDS) during the first week of postnatal life. METHODS: Serum free thyroxine (T4) was measured by direct equilibrium dialysis, total thyroxine (TT4) by radioimmunoassay, and thyrotropin by a sensitive immunometric assay in 90 premature infants (45 healthy control subjects and 45 with RDS) during their first week of life after 25 to 30 weeks of gestation. Infants in the RDS group received exogenous surfactant therapy. RESULTS: Free T4 and thyrotropin concentrations of infants were not significantly different between RDS and control groups. As expected, infants with RDS had significantly lower serum total T4 concentrations compared with control infants (p < 0.001). This difference was present even after stratification for gestational age (25- to 27-week group, p = 0.012; 28- to 30-week group, p = 0.002). Lower total T4 concentrations were attributable to lower T4 binding to serum proteins among infants with RDS compared with control subjects, especially in the 25- to 27-week gestation group (p = 0.0075). CONCLUSION: These data indicate that pituitary-thyroid function is not altered in premature infants with RDS. The low total T4 state in these premature infants is attributable solely to reduced serum T4 binding, as is often seen in acute nonthyroidal illnesses.
L Job; J R Emery; A O Hopper; D D Deming; G A Nystrom; S J Clark; J C Nelson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  131     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-30     Completed Date:  1997-10-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  489-92     Citation Subset:  AIM; IM    
Department of Pediatrics, Loma Linda University School of Medicine, CA 92350, USA.
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MeSH Terms
Case-Control Studies
Gestational Age
Infant, Newborn
Pulmonary Surfactants / therapeutic use
Respiratory Distress Syndrome, Newborn / blood*,  drug therapy
Thyrotropin / blood*
Thyroxine / blood*
Reg. No./Substance:
0/Pulmonary Surfactants; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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