Document Detail

Serum folate and homocysteine levels in patients with obsessive-compulsive disorder.
MedLine Citation:
PMID:  16194269     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that folate deficiency, increased homocysteine, impaired metylation have been identified in depressive disorder. Recently, growing research has resulted in the biological association between obsessive-compulsive disorder (OCD) and affective disorders. Therefore, in the present study it was evaluated whether or not folate and homocysteine levels changed. Serum folate and homocysteine concentrations were measured in 23 patients with OCD and in same number of controls. In addition, all patients were assessed by Yale-Brown Obsession Compulsion Scale (Y-BOCS). Serum folate values were significantly lower in OCD patients than in controls, while homocysteine concentrations were higher in patients compared with controls. Serum folate values were significantly and negatively related to Y-BOCS scores. Total serum homocysteine concentrations were positively correlated to Y-BOCS scores and the duration of illness. There was a trend toward a negative correlation between the concentrations of serum folate and homocysteine. In conclusion, we identified that a group of patients with OCD might have folate deficiency, higher homocysteine levels and probable impaired metylation and monoamine metabolism.
Murad Atmaca; Ertan Tezcan; Murat Kuloglu; Ozlem Kirtas; Bilal Ustundag
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  59     ISSN:  1323-1316     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-30     Completed Date:  2006-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  616-20     Citation Subset:  IM    
Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey.
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MeSH Terms
Folic Acid / blood*
Homocysteine / blood*
Middle Aged
Obsessive-Compulsive Disorder / blood*
Psychiatric Status Rating Scales
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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