| Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men. | |
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MedLine Citation:
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PMID: 20928885 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A normal mineral metabolism is integral for skeletal development and preservation of bone integrity. Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating factor that decreases serum concentrations of inorganic phosphorous (P(i) ) and 1,25-dihydroxyvitamin D(3) [1,25(OH)(2) D(3) ]. Increased FGF-23 expression is a direct or indirect culprit in several skeletal disorders; however, the relation between FGF-23 and fracture risk remains undetermined. We evaluated the prospective relation between serum intact FGF-23 (measured by a two-site monoclonal antibody ELISA) and fracture risk employing the Swedish part of the population-based Osteoporotic Fractures in Men Study (MrOS; n = 2868; mean age 75.4 ± 3.2 years; median follow-up period 3.35 years). The incidence of at least one validated fracture after baseline was 20.4 per 1000 person-years. FGF-23 was directly related to the overall fracture risk [age-adjusted hazard ratio (HR) per SD increase = 1.20, 95% confidence interval (CI) 1.03-1.40] and vertebral fracture risk (HR = 1.33, 95% CI 1.02-1.75). Spline models revealed a nonlinear relation between FGF-23 and fracture risk, with the strongest relation at FGF-23 levels above 55.7 pg/mL. FGF-23 levels above 55.7 pg/mL also were associated with an increased risk for hip and nonvertebral fractures (HR = 2.30, 95% CI 1.16-4.58, and HR = 1.63, 95% CI 1.01-2.63, respectively). These relations remained essentially unaltered after adjustment for bodymass index (BMI), bone mineral density (BMD), glomerular filtration rate, 25(OH)(2) D(3) , parathyroid hormone (PTH), and other fracture risk factors. In conclusion, FGF-23 is a novel predictor of fracture risk in elderly men. © 2011 American Society for Bone and Mineral Research. |
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Authors:
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Majd Ai Mirza; Magnus K Karlsson; Dan Mellström; Eric Orwoll; Claes Ohlsson; Osten Ljunggren; Tobias E Larsson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Volume: 26 ISSN: 1523-4681 ISO Abbreviation: J. Bone Miner. Res. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610640 Medline TA: J Bone Miner Res Country: United States |
Other Details:
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Languages: eng Pagination: 857-64 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Bone and Mineral Research. |
Affiliation:
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Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden. majd.mirza@medsci.uu.se. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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