Document Detail

Serum fibrin(ogen) degradation products in diagnosis of deep-vein thrombosis and pulmonary embolism after hip surgery.
MedLine Citation:
PMID:  49650     Owner:  NLM     Status:  MEDLINE    
Levels of fibrin(ogen) degradation products (F.D.P.) have been measured by radioimmunoassay for degradation product E (FgE) and by tanned-red-cell haemagglutination-inhibition immunoassay (T.R.C.H.I.I.) in the serum of thirty-three patients undergoing total hip replacement. Levels of F.D.P. did not correlate with thermographic evidence of deep-venous thrombosis. However, in 34 patients with pulmonary embolism, levels of F.D.P. measured by the T.R.C.H.I.I. were transiently raised at the time of embolus, and FgE concentrations were increased for up to 5 days preceding the embolus. Since the measurments of FgE is simple, convenient, and cheap, this estimation might constitute a valuable screening test for major thromboembolic episodes in the postoperative period.
E D Cooke; S A Bowcock; M F Pilcher; R M Ibbotson; Y B Gordon; C M Sola; T Chard; M E Ainsworth
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-09-18     Completed Date:  1975-09-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  51-4     Citation Subset:  AIM; IM    
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MeSH Terms
Fibrin / analysis*
Fibrinogen / analysis*
Hemagglutination Inhibition Tests
Hip / surgery*
Middle Aged
Postoperative Complications / blood*
Pulmonary Embolism / blood,  diagnosis*,  etiology
Thrombophlebitis / blood,  diagnosis*,  etiology
Reg. No./Substance:
9001-31-4/Fibrin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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