Document Detail


Serum ferritin and survival of renal transplant recipients: a prospective 10-year cohort study.
MedLine Citation:
PMID:  12732929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased serum ferritin is frequent in renal transplant recipients. This reflects iron overload due to blood transfusions given to treat renal anaemia. Previous studies suggested excess mortality in non-renal transplant recipients with iron overload. We hypothesized that serum ferritin levels above 1100 ng/ml may be associated with increased long-term mortality in renal transplant recipients. Twenty consecutive renal transplant recipients with high levels of serum ferritin and 20 renal transplant recipients with normal serum ferritin levels, matched for age and gender, were prospectively studied for 10 years. Nine patients (45%) with increased serum ferritin died during follow-up, compared to four controls (20%). Univariate and multivariate analysis identified multiple blood transfusions (>40 units) prior to transplantation as being associated with higher mortality in renal transplant recipients (risk ratio (RR): 3.1, confidence interval (CI): 1.1-9.2; P=0.03). These data suggest that serum ferritin levels above 1100 ng/ml due to multiple blood transfusions causing iron overload is a relevant factor that increases mortality.
Authors:
Stefan Herget-Rosenthal; Guido Gerken; Thomas Philipp; Gerald Holtmann
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Publication Detail:
Type:  Journal Article     Date:  2003-05-06
Journal Detail:
Title:  Transplant international : official journal of the European Society for Organ Transplantation     Volume:  16     ISSN:  0934-0874     ISO Abbreviation:  Transpl. Int.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-23     Completed Date:  2004-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908516     Medline TA:  Transpl Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  642-7     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology and Hepatology, Medizinische Klinik, Universitätsklinikum Essen, Hufelandstrasse 52, 45122, Essen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Transfusion / adverse effects
Case-Control Studies
Cohort Studies
Female
Ferritins / blood*
Humans
Kidney Transplantation / mortality*
Male
Middle Aged
Multivariate Analysis
Postoperative Period
Preoperative Care / adverse effects
Prospective Studies
Survival Analysis
Time Factors
Chemical
Reg. No./Substance:
9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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