Document Detail

Serum fatty acids and cardiovascular risk factors in sudden sensorineural hearing loss: a case-control study.
MedLine Citation:
PMID:  20336917     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We analyzed the relationships between sudden sensorineural hearing loss (SSNHL) and serum levels of fatty acids, total cholesterol, low-density lipoproteins (LDLs), and the antioxidant coenzyme Q10. METHODS: Forty-three patients with SSNHL and 43 healthy subjects were enrolled in the study. The main outcome measures were serum levels of fatty acids, coenzyme Q10, total cholesterol, and LDLs. RESULTS: On univariate logistic regression analysis, high levels of total cholesterol (p < 0.001), LDLs (p = 0.024), behenic acid (p < 0.001), docosahexaenoic acid (p < 0.001), linolenic acid (p = 0.017), and oleic acid (p < 0.001) and low levels of coenzyme Q10 (p < 0.001) and nervonic acid (p < 0.001) were associated with an elevated risk of SSNHL. On multivariate analysis, only hypercholesterolemia (p = 0.15) and low levels of coenzyme Q10 (p = 0.02) and nervonic acid (p = 0.005) were significantly associated with SSNHL. CONCLUSIONS: This is the first report of low serum levels of nervonic acid as an independent risk factor for SSNHL. Considering that hypercholesterolemia, high serum levels of LDL, and low serum levels of the antioxidant coenzyme Q10 were associated with SSNHL as well, we hypothesize that saturated fatty acids may play a role in determining the dysmetabolic state in a subset of SSNHL patients. Together, these findings suggest that not only total cholesterol and LDL levels, but also fatty acid determination, may help identify SSNHL patients with cardiovascular risk factors.
Gabriella Cadoni; Alessandro Scorpecci; Francesca Cianfrone; Sara Giannantonio; Gaetano Paludetti; Silvio Lippa
Related Documents :
4075697 - Non-enzymatic glycosylation of plasma lipoproteins in vitro.
1402397 - Influence of eicosapentaenoic acid (20:5, n-3) on secretion of lipoproteins in caco-2 c...
10423617 - Effect of probucol therapy on plasma fatty acid composition during postprandial lipemia...
1930197 - Lipoprotein-incorporated pregnenolone fatty acid esters act as substrate for ovarian pr...
18516557 - Application of lipidomics and metabolomics to the study of adipose tissue.
20145247 - Myosin cross-reactive antigen of streptococcus pyogenes m49 encodes a fatty acid double...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  119     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  82-8     Citation Subset:  AIM; IM    
Institutes of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Cardiovascular Diseases / blood*,  epidemiology,  etiology
Fatty Acids / blood*
Follow-Up Studies
Hearing Loss, Sudden / blood,  complications*
Italy / epidemiology
Middle Aged
Retrospective Studies
Risk Factors
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endoscopic assessment of the nasopharynx: an objective score of abnormality to predict the likelihoo...
Next Document:  Imported acute and isolated glottic paracoccidioidomycosis.