| Serum fatty acid profiles after intravenous medium chain triglyceride administration. | |
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MedLine Citation:
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PMID: 2586236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The serum fatty acid profiles of patients receiving either intravenous medium or long chain triglycerides were studied. Seventeen hospitalized patients, dependent on total parenteral nutrition, were randomly enrolled into a prospective study. The total parenteral nutrition (TPN) delivered amino acids and glucose and either a 75% medium chain triglyceride and 25% long chain triglyceride (MCT group) physical mixture or all long chain triglyceride (LCT group), as the respective fat sources. The amino acids and glucose were given continuously, and the lipid was given for 10 hours each day over five days. Fatty acid profiles on serum triglycerides and free fatty acids were done in the morning before any lipid was given and also later in the afternoon, near the end of the lipid administration, on days 1, 3 and 5. Medium chain fatty acids rose quickly in the triglyceride fraction in patients given MCT. Rapid MCT hydrolysis occurred as evidenced by the appearance of medium chain fatty acids in the free fatty acid fraction in the afternoon sampling. Clearance of the hydrolyzed medium chain free fatty acids (MCFFA) occurred so that little, if any, were present in the morning sampling one day later. Long chain fatty acids, as either triglycerides or free fatty acids, showed expected increases during the daily infusion, but not of such relative magnitude as the medium chain fatty acids. Medium chain fatty acid incorporation into the phospholipid or cholesterol ester fractions by the end of the five-day feeding period was present but minimal.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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E A Mascioli; S Lopes; S Randall; K A Porter; G Kater; Y Hirschberg; V K Babayan; B R Bistrian; G L Blackburn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lipids Volume: 24 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1990-01-03 Completed Date: 1990-01-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 793-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Harvard Medical School, New England Deaconess Hospital, Boston, MA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arachidonic Acids / blood Cholesterol Esters / blood Decanoic Acids / blood Diet Fatty Acids / blood* Female Humans Injections, Intravenous Linoleic Acids / blood Linolenic Acids / blood Male Middle Aged Oleic Acids / blood Palmitic Acids / blood Phospholipids / blood Stearic Acids / blood Time Factors Triglycerides / administration & dosage* |
| Grant Support | |
ID/Acronym/Agency:
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GM30632/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Cholesterol Esters; 0/Decanoic Acids; 0/Fatty Acids; 0/Linoleic Acids; 0/Linolenic Acids; 0/Oleic Acids; 0/Palmitic Acids; 0/Phospholipids; 0/Stearic Acids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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