| Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers. | |
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MedLine Citation:
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PMID: 19394980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fatty acid binding protein (FABP) 4 chaperones free fatty acids (FFAs) in the adipocytes during lipolysis. Serum FFA relates to metabolic syndrome, and serum FABP4 is emerging as a novel risk marker. In 36 overweight/obese women, serum FABP4 and FFA were measured hourly during 5-hour oral glucose tolerance test. Insulin resistance was determined using frequently sampled intravenous glucose tolerance test. Serum lipids and inflammation markers were measured at fasting. During oral glucose tolerance test, serum FABP4 decreased by 40%, reaching its nadir at 3 hours (from 45.3 +/- 3.1 to 31.9 +/- 1.6 ng/mL), and stayed below the baseline at 5 hours (35.9 +/- 2.2 ng/mL) (P < .0001 for both, compared with the baseline). Serum FFA decreased by 10-fold, reaching a nadir at 2 hours (from 0.611 +/- 0.033 to 0.067 +/- 0.004 mmol/L), then rebounded to 0.816 +/- 0.035 mmol/L at 5 hours (P < .001 for both, compared with baseline). Both fasting FABP4 and nadir FABP4 correlated with obesity. Nadir FABP4 correlated also with insulin resistance parameters from frequently sampled intravenous glucose tolerance test and with inflammation. Nadir FFA, but not fasting FFA, correlated with the metabolic syndrome parameters. In conclusion, fasting FABP4 related to metabolic risk markers more strongly than fasting FFA. Nadir FABP4 and nadir FFA measured after glucose loading may provide better risk assessment than the fasting values. |
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Authors:
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Sidika E Karakas; Rogelio U Almario; Kyoungmi Kim |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 58 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-08 Completed Date: 2009-07-13 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1002-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition and Vascular Medicine, The University of California at Davis, Davis, CA 95817, USA. sekarakas@ucdavis.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Glucose / metabolism* C-Reactive Protein / metabolism Fatty Acid-Binding Proteins / blood* Fatty Acids, Nonesterified / blood* Female Glucose Tolerance Test Humans Insulin Resistance / physiology Interleukin-1beta / metabolism Interleukin-6 / blood, metabolism Metabolic Syndrome X / blood*, metabolism Middle Aged Obesity / blood*, metabolism Statistics, Nonparametric Tumor Necrosis Factor-alpha / metabolism Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AT002280/AT/NCCAM NIH HHS; R21 AT002280-01A2/AT/NCCAM NIH HHS; R21 AT003401-01A1/AT/NCCAM NIH HHS; RR 024146/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/FABP4 protein, human; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids, Nonesterified; 0/Interleukin-1beta; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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