Document Detail


Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone.
MedLine Citation:
PMID:  6489545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum estradiol (E2) levels and resolution of endometriosis were evaluated in 42 women after 75 days of danazol treatment. Complete or almost complete remission occurred when radioimmunoassay E2 levels were less than 15 pg/ml in extensive, less than 22 pg/ml in severe, and less than 41 pg/ml in moderate endometriosis. E2 less than or equal to 20 pg/ml occurred in 23% of 104 patients given 400 mg every 12 hours but in none weighing over 150 pounds (68 kg). E2 greater than 100 pg/ml occurred in 7%. The mean E2 levels were identical with 400 mg every 12 hours and 200 mg every 8 hours. The E2 level was 40% lower with 200 mg every 6 hours than with 400 mg every 12 hours (P less than 0.001). Dexamethasone further decreased E2 levels by 61% (P less than 0.001). Spironolactone decreased androgen symptoms but increased E2 levels by 49% (P less than 0.01).
Authors:
R P Dickey; S N Taylor; D N Curole
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  42     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-18     Completed Date:  1984-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  709-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Body Weight
Danazol / administration & dosage,  therapeutic use*
Dexamethasone / administration & dosage,  therapeutic use*
Drug Administration Schedule
Drug Therapy, Combination
Endometriosis / blood,  drug therapy*
Estradiol / blood*
Female
Humans
Pelvic Neoplasms / blood,  drug therapy*
Pregnadienes / therapeutic use*
Progesterone / blood
Radioimmunoassay
Spironolactone / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Pregnadienes; 17230-88-5/Danazol; 50-02-2/Dexamethasone; 50-28-2/Estradiol; 52-01-7/Spironolactone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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