Document Detail


Serum erythropoietin concentrations measured by radioimmunoassay in normal, polycythemic, and anemic dogs and cats.
MedLine Citation:
PMID:  8176658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum erythropoietin (Epo) concentrations were measured by radioimmunoassay (RIA) in normal, polycythemic, and anemic dogs and cats. The serum Epo concentration in normal dogs (n = 25) ranged from 7 to 37 mU/mL (median, 20 mU/mL); and in normal cats (n = 11) ranged from 9 to 38 mU/mL (median, 18 mU/mL). Polycythemic animals (PCV > 55% in dogs, > 45% in cats) were classified as those with primary (polycythemia vera), secondary, or polycythemia of uncertain etiology. Dogs with polycythemia vera (PV, n = 8) had a median serum Epo concentration in the normal range (17 mU/mL); cats with PV (n = 7) also had a median serum Epo concentration that was within the normal range (10 mU/mL). In the category of secondary polycythemias, dogs (n = 7) (median, 30.7 mU/mL) and cats (n = 2) had normal Epo concentrations. The median serum Epo concentration was significantly decreased (P < .05) in dogs with PV compared with dogs with secondary polycythemias. The median serum Epo concentrations in dogs (n = 13) and cats (n = 5) with anemias not due to chronic renal disease were significantly increased (P < .05) compared with normal dogs and cats. In cats with anemias due to chronic renal disease (n = 5) the median serum Epo concentration was not significantly different from normal cats. The measurement of the serum EPO concentration may be useful in assessment of anemia or polycythemia but the overlap of values with the normal range in all groups evaluated limit its diagnostic use.
Authors:
S M Cook; C D Lothrop
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  8     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    1994 Jan-Feb
Date Detail:
Created Date:  1994-06-06     Completed Date:  1994-06-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-25     Citation Subset:  IM    
Affiliation:
Department of Environmental Practice, University of Tennessee, College of Veterinary Medicine, Knoxville.
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MeSH Terms
Descriptor/Qualifier:
Anemia / blood,  veterinary*
Animals
Cat Diseases / blood*
Cats
Dog Diseases / blood*
Dogs
Erythropoietin / blood*
Female
Male
Polycythemia / blood,  veterinary*
Radioimmunoassay / veterinary
Grant Support
ID/Acronym/Agency:
HL-15647/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
11096-26-7/Erythropoietin
Comments/Corrections
Comment In:
J Vet Intern Med. 1994 Jul-Aug;8(4):314-5   [PMID:  7848480 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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