Document Detail


Serum erythropoietin concentrations fail to increase after significant phlebotomy losses in ill preterm infants.
MedLine Citation:
PMID:  9447534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RESULTS: Before the first transfusion, erythropoietin concentrations were 68.9 +/- 36.2 mU/ml (range 0 to 205 mU/ml) at 5 ml/kg blood out, 17.4 +/- 8.9 mU/ml at 10 ml/kg, and 4.8 +/- 2.6 mU/ml at 15 ml/kg. Erythropoietin concentrations did not increase in any patients despite increasing phlebotomy losses.
CONCLUSION: Serum erythropoietin concentrations in ill preterm infants do not increase in the face of significant blood loss. Although the mechanistic explanation for this failure is unclear, it likely contributes to the transfusion requirements of this population.
Authors:
R K Ohls; J Harcum; Y Li; G Davila; R D Christensen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  17     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    1997 Nov-Dec
Date Detail:
Created Date:  1998-03-04     Completed Date:  1998-03-04     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  465-7     Citation Subset:  IM    
Affiliation:
Division of Neonatology, University of Florida College of Medicine, Gainesville, USA.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Neonatal / blood*,  etiology
Enzyme-Linked Immunosorbent Assay
Erythropoiesis / physiology
Erythropoietin / blood*,  therapeutic use
Hematocrit
Humans
Infant, Newborn
Infant, Premature, Diseases / blood*,  therapy
Infusions, Intravenous
Phlebotomy / adverse effects*
Recombinant Proteins
Respiration, Artificial
Treatment Outcome
Grant Support
ID/Acronym/Agency:
HD-00096/HD/NICHD NIH HHS; HD-00988/HD/NICHD NIH HHS; HL-44951/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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