Document Detail

Serum erythrocyte sedimentation rate is higher among ethnic South Asian compared to ethnic Chinese ischemic stroke patients. Is this attributable to metabolic syndrome or central obesity?
MedLine Citation:
PMID:  18930475     Owner:  NLM     Status:  MEDLINE    
Inflammation, a vascular risk factor, is more pronounced among ethnic South Asians compared to ethnic Chinese in the general population. We compared serum erythrocyte sedimentation rate (ESR) levels between ethnic South Asian and Chinese acute ischemic stroke patients, and further investigated if metabolic syndrome or central obesity could account for any difference detected. We prospectively recruited consecutive ischemic stroke patients within seven days of onset. Measurement of serum ESR was performed within two days of admission. Median serum ESR was higher among the 55 ethnic South Asian (16 mm/h IQR 3-35) compared to the 165 ethnic Chinese patients (9 mm/h IQR 4-19), p=0.004). Serum ESR was correlated with age. Higher serum ESR was associated with female gender, non-smokers, patients with central obesity and low high-density lipoprotein (HDL) cholesterol. Using regression analysis, South Asian ethnicity remained significantly associated with serum ESR, independent of age, gender, smoking status, metabolic syndrome, central obesity and low HDL. Ethnic South Asian ischemic stroke patients have a higher inflammatory state compared to ethnic Chinese patients. As the higher inflammatory state is independent of demographic and risk factors, we propose an underlying genetic or cultural basis for the ethnic difference.
Deidre Anne De Silva; Fung-Peng Woon; Christopher Chen; Hui-Meng Chang; Meng-Cheong Wong
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Publication Detail:
Type:  Journal Article     Date:  2008-10-18
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  276     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  126-9     Citation Subset:  IM    
National Neuroscience Institute, Singapore General Hospital Campus, Singapore.
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MeSH Terms
Asia, Southeastern / ethnology
Asian Continental Ancestry Group / ethnology
Blood Sedimentation*
Metabolic Diseases / complications*,  epidemiology
Middle Aged
Obesity / complications*,  epidemiology
Prospective Studies
Regression Analysis
Retrospective Studies
Stroke / blood*,  epidemiology,  ethnology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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