| Serum enzyme status of Chios ewes fed increasing amounts of copper from copper sulfate. | |
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MedLine Citation:
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PMID: 20045542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed to evaluate effects of orally administered copper (Cu) to Chios sheep breed on serum levels of aspartate aminotransferase (AST), l-alanine aminotransferase (ALT), lactate deydrogenase (LDH) and alkaline phosphatase (ALP), in order to establish a practical and effective method in diagnosing the prehemolytic stage of chronic Cu poisoning. Eighteen ewes were allocated to three treatments of six ewes and fed a diet that contained 16.4 mg/day of Cu. Ewes in treatment Cu-0 received no additional Cu (control), while those in treatments Cu-60 and Cu-95 received 60 and 95 mg additional Cu/day, respectively, as an oral solution of copper sulfate. Therefore the ewes in treatment Cu-0, Cu-60 and Cu-95 consumed 16.4, 76.4 and 111.4 mg Cu/day, respectively. Serum enzyme levels were similar among treatments and all ewes remained clinically healthy until the end of the experiment. Results suggest that Chios ewes exhibit tolerance to Cu supplementation for up to 6 weeks. |
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Authors:
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V A Bampidis; V Christodoulou; A Chatzipanagiotou; E Sossidou; A Salangoudis |
Publication Detail:
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Type: Journal Article Date: 2010-01-04 |
Journal Detail:
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Title: Research in veterinary science Volume: 88 ISSN: 1532-2661 ISO Abbreviation: Res. Vet. Sci. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-29 Completed Date: 2010-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: England |
Other Details:
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Languages: eng Pagination: 456-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Animal Production, School of Agricultural Technology, Alexander Technological Educational Institute, 57400 Thessaloniki, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Alanine Transaminase / blood, drug effects Alkaline Phosphatase / blood, drug effects Animals Aspartate Aminotransferases / blood, drug effects Copper / administration & dosage, pharmacology* Copper Sulfate / pharmacology Enzymes / blood*, drug effects Female L-Lactate Dehydrogenase / blood, drug effects Sheep / blood, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Enzymes; 7440-50-8/Copper; 7758-98-7/Copper Sulfate; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase |
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