Document Detail


Serum and duodenal alkaline phosphatase levels in fed and fasted magnesium deficient rats.
MedLine Citation:
PMID:  864516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats depleted of magnesium for 13 days were killed after 18 to 20 hours of fasting or 2 hours after consumption of a standard-sized meal. Serum and duodenal alkaline phosphatase (AP) were reduced in fasted magnesium depleted rats compared to pair-fed and ad libitum-fed controls. With refeeding, serum alkaline phosphatase levels rose significantly in all groups, but the levels in refed Mg deficient rats remained below serum levels of fasted control rats. Inhibition of AP activity with L-phenylalanine and urea suggested that the differences in AP levels of fasted and fed rats were mainly due to enzymes of intestinal origin. Intestinal AP levels increased after feeding in all groups, but were proportionately greatest in Mg depleted rats. The pattern of serum and duodenal AP in fed and fasted rats and the results of polyacrylamide disc gel electrophoresis (PADGE) in duodenal AP extracts suggest that Mg depletion alters the release of AP into the blood that normally occurs in response to feeding.
Authors:
P J Neafsey; R Schwartz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  107     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-07-18     Completed Date:  1977-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1061-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alkaline Phosphatase / antagonists & inhibitors,  blood,  metabolism*
Animals
Body Weight
Diet
Duodenum / enzymology*
Fasting*
Feeding Behavior
Intestinal Mucosa / enzymology
Magnesium / blood
Magnesium Deficiency / enzymology*
Male
Phenylalanine / pharmacology
Rats
Urea / pharmacology
Chemical
Reg. No./Substance:
57-13-6/Urea; 63-91-2/Phenylalanine; 7439-95-4/Magnesium; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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