Document Detail

Serum digoxin levels in neonates whose weights are less than 1,500 grams.
MedLine Citation:
PMID:  7162876     Owner:  NLM     Status:  MEDLINE    
Digoxin was given to 29 infants in congestive heart failure and weighing less than 1,500 gm. All the infants were considered to have an isolated patent ductus arteriosus and were recovering from the respiratory distress syndrome. Forty-eight serum digoxin levels were measured after 4 or more days on twice daily parenteral maintenance therapy and a significant correlation obtained between the dose and resultant serum level (P less than .001). A total parenteral maintenance dose of 5 micrograms/kg produced a serum level of 2.4 ng/ml (+/- 1.2 ng). This is a much lower dose regime than in frequently recommended and underscores the need for caution in digitalizing small premature infants.
M W Patterson; G Reid; G G Sandor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pharmacology (New York, N.Y.)     Volume:  2     ISSN:  0270-322X     ISO Abbreviation:  Pediatr Pharmacol (New York)     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8400778     Medline TA:  Pediatr Pharmacol (New York)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
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MeSH Terms
Digoxin / administration & dosage,  adverse effects,  blood*
Heart Failure / blood
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature
Reg. No./Substance:

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