| Serum digoxin levels in neonates whose weights are less than 1,500 grams. | |
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MedLine Citation:
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PMID: 7162876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Digoxin was given to 29 infants in congestive heart failure and weighing less than 1,500 gm. All the infants were considered to have an isolated patent ductus arteriosus and were recovering from the respiratory distress syndrome. Forty-eight serum digoxin levels were measured after 4 or more days on twice daily parenteral maintenance therapy and a significant correlation obtained between the dose and resultant serum level (P less than .001). A total parenteral maintenance dose of 5 micrograms/kg produced a serum level of 2.4 ng/ml (+/- 1.2 ng). This is a much lower dose regime than in frequently recommended and underscores the need for caution in digitalizing small premature infants. |
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Authors:
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M W Patterson; G Reid; G G Sandor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric pharmacology (New York, N.Y.) Volume: 2 ISSN: 0270-322X ISO Abbreviation: Pediatr Pharmacol (New York) Publication Date: 1982 |
Date Detail:
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Created Date: 1983-04-07 Completed Date: 1983-04-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8400778 Medline TA: Pediatr Pharmacol (New York) Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 217-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Digoxin
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administration & dosage,
adverse effects,
blood* Heart Failure / blood Humans Infant, Low Birth Weight* Infant, Newborn Infant, Premature |
| Chemical | |
Reg. No./Substance:
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20830-75-5/Digoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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