Document Detail


Serum digoxin levels in neonates whose weights are less than 1,500 grams.
MedLine Citation:
PMID:  7162876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Digoxin was given to 29 infants in congestive heart failure and weighing less than 1,500 gm. All the infants were considered to have an isolated patent ductus arteriosus and were recovering from the respiratory distress syndrome. Forty-eight serum digoxin levels were measured after 4 or more days on twice daily parenteral maintenance therapy and a significant correlation obtained between the dose and resultant serum level (P less than .001). A total parenteral maintenance dose of 5 micrograms/kg produced a serum level of 2.4 ng/ml (+/- 1.2 ng). This is a much lower dose regime than in frequently recommended and underscores the need for caution in digitalizing small premature infants.
Authors:
M W Patterson; G Reid; G G Sandor
Related Documents :
15926396 - Unusual findings during abdominal placement of a ventriculoperitoneal shunt: report of ...
1731006 - Left ventricular mechanics in the preterm infant and their effect on the measurement of...
16779846 - Diameter of paediatric sized flexible bronchoscopes: when size matters.
19843236 - Prophylactic indomethacin in extremely premature infants between 23 and 24 weeks gestat...
7949796 - Free-radical-induced lipid peroxidation during the early neonatal period.
20580626 - Patient selection and prognostication with hypothermia treatment.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pharmacology (New York, N.Y.)     Volume:  2     ISSN:  0270-322X     ISO Abbreviation:  Pediatr Pharmacol (New York)     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8400778     Medline TA:  Pediatr Pharmacol (New York)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Digoxin / administration & dosage,  adverse effects,  blood*
Heart Failure / blood
Humans
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature
Chemical
Reg. No./Substance:
20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Patterns of preadmission medication use among hospitalized children.
Next Document:  Quantitative electrocardiographic effects of digoxin in newborn and adult rats.