Document Detail

Serum digoxin concentrations in atrial fibrillation: a review.
MedLine Citation:
PMID:  7049644     Owner:  NLM     Status:  MEDLINE    
Studies evaluating the relationship of serum digoxin concentrations (SDCs) with pharmacodynamic effects in atrial fibrillation have important limitations. In general, a poor correlation is found between SDC and ventricular rate, but this is understandable, considering the many other factors that affect conduction through the atrioventricular node. The ventricular rate, although a clinically important and easily monitored parameter, may not always be a good measure of digoxin effect. In certain patients, signs and symptoms of toxicity may develop before the desired decrease in heart rate. The SDC may provide, in many cases, information that cannot be obtained solely from the clinical response, but is of great relevance to therapeutic decision making.
J E Masuhara; R L Lalonde
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drug intelligence & clinical pharmacy     Volume:  16     ISSN:  0012-6578     ISO Abbreviation:  Drug Intell Clin Pharm     Publication Date:    1982 Jul-Aug
Date Detail:
Created Date:  1982-10-21     Completed Date:  1982-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0212457     Medline TA:  Drug Intell Clin Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  543-6     Citation Subset:  IM    
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MeSH Terms
Atrial Fibrillation / drug therapy*
Digoxin / adverse effects,  blood*,  therapeutic use
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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