Document Detail

Serum deoxycytidylate deaminase as an index of high-risk pregnancy.
MedLine Citation:
PMID:  7073998     Owner:  NLM     Status:  MEDLINE    
Serum deoxycytidylate deaminase (EC, dCMP deaminase) activity was routinely estimated over 7 years in 2460 pregnancies. The results confirm that elevated dCMP deaminase activity (greater than 4.8 units) is associated with the development of pre-eclampsia but not with essential hypertension in pregnancy; a high rising level can precede eclampsia. Elevated enzyme activity was also found in women who developed jaundice in pregnancy and in some with apparently normal pregnancies. An unexpected finding was that these so called 'false positive' high levels were associated with all the unexplained intrauterine fetal deaths that occurred later in pregnancy. Although elevated dCMP deaminase levels may be associated with a normal outcome, persisting high levels indicate the need for careful monitoring of fetal well being and, in the presence of any other sign of placental insufficiency, delivery should be expedited.
G F Williams; D D Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  89     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-07-19     Completed Date:  1982-07-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  309-13     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Enzyme Tests*
DCMP Deaminase / blood*
False Positive Reactions
Fetal Death / diagnosis
Jaundice / diagnosis
Nucleotide Deaminases / blood*
Pre-Eclampsia / diagnosis
Pregnancy Complications / diagnosis*,  enzymology
Reg. No./Substance:
EC 3.5.4.-/Nucleotide Deaminases; EC Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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