Document Detail


Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.
MedLine Citation:
PMID:  1835658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circulating levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol were studied in 86 patients with dementia; 45 with Alzheimer's disease and 41 with multi-infarct dementia. Compared to an elderly control group, after adjustment for age and sex, patients with Alzheimer's disease were found to have lower serum levels of DHEAS. We found a covariation between serum albumin and DHEAS levels, which may be of importance regarding peripheral hormone concentration in patients with dementia. These findings may provide evidence for a role of DHEAS in amnestic disorder in humans, either reflecting or contributing to the course of dementing diseases.
Authors:
B Näsman; T Olsson; T Bäckström; S Eriksson; K Grankvist; M Viitanen; G Bucht
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  30     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-01-07     Completed Date:  1992-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  684-90     Citation Subset:  IM    
Affiliation:
Department of Geriatric Medicine, Umeå University Hospital, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / blood*,  diagnosis*
Blood-Brain Barrier / physiology
Dehydroepiandrosterone / analogs & derivatives*,  blood
Dehydroepiandrosterone Sulfate
Dementia, Multi-Infarct / blood*,  diagnosis*
Female
Humans
Hydrocortisone / blood
Male
Middle Aged
Nerve Degeneration / physiology
Neuropsychological Tests
Radioimmunoassay
Serum Albumin / metabolism
Chemical
Reg. No./Substance:
0/Serum Albumin; 50-23-7/Hydrocortisone; 53-43-0/Dehydroepiandrosterone; 651-48-9/Dehydroepiandrosterone Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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