Document Detail

Serum cytokine levels in autoimmune and non-autoimmune hyperthyroid states.
MedLine Citation:
PMID:  10625876     Owner:  NLM     Status:  MEDLINE    
Although the role of interleukin-2 (IL-2) and interferon gamma (gammaIFN) is still poorly understood in hyperthyroid diseases, it is reasonable to assume that these cytokines may be present at higher levels in Graves' disease (GD) than in other primarily non-autoimmune thyroid diseases. In order to look for an easy method to distinguish GD from primarily non-autoimmune causes of hyperthyroidism, we compared 13 healthy individuals with 21 treated and untreated hyperthyroid GD patients and with 19 patients with hyperthyroidism due to other etiologies: 7 cases of multinodular goiter, 5 cases of excessive hormone replacement and 7 cases of amiodarone-associated hyperthyroidism. All patients presented low TSH levels and a dubious clinical thyroid state. We found a good correlation between TSH and serum IL-2 levels (r = 0.56; P<0.01). Serum IL-2 (P<0.01) and gammaIFN (P<0.01) levels were lower in the hyperthyroid group of patients than in control subjects, suggesting a depressed TH1 pattern in the T-cell subset of hyperthyroid patients. GD had normal IL-2 levels, while patients with other forms of thyrotoxicosis presented decreased IL-2 levels (P<0.05). There was no difference between treated and untreated GD patients. We suggest that the direct measurement of serum IL-2 level may help to confirm hyperthyroidism caused by GD.
L S Ward; G A Fernandes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  33     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-06-05     Completed Date:  2000-06-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  65-9     Citation Subset:  IM    
Laboratório de Genética Molecular do Câncer, Departamento de Clínica Médica, Universidade Estadual de Campinas, Campinas, SP, Brasil.
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MeSH Terms
Autoantibodies / blood
Cytokines / blood*
Graves Disease / blood,  diagnosis
Hyperthyroidism / blood*,  diagnosis
Immunoenzyme Techniques
Interferon-gamma / blood
Interleukin-2 / blood
Middle Aged
Statistics, Nonparametric
T-Lymphocyte Subsets / chemistry
Thyrotropin / blood
Reg. No./Substance:
0/Autoantibodies; 0/Cytokines; 0/Interleukin-2; 82115-62-6/Interferon-gamma; 9002-71-5/Thyrotropin

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