| Serum cytokine and chemokine profiles in neonates with meconium aspiration syndrome. | |
| | |
MedLine Citation:
|
PMID: 18346989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Various inflammatory cytokines and chemokines are thought to be associated with the pathophysiology of meconium aspiration syndrome. To clarify any such association, we compared various serum cytokine and chemokine profiles in patients with and without meconium aspiration syndrome. PATIENTS AND METHODS: Using a highly sensitive fluorescence microsphere method, 17 types of cytokines and chemokines in sera were measured in 11 neonatal patients with meconium aspiration syndrome, 16 neonatal patients without meconium aspiration syndrome, and 9 healthy children. RESULTS: The concentrations of 8 types of proinflammatory cytokines and chemokines were significantly higher in the meconium aspiration syndrome group than in healthy controls: interleukin-1beta, interleukin-6, interleukin-8, granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor, interferon-gamma, macrophage inflammatory protein-1beta, and tumor necrosis factor-alpha. Six types of proinflammatory cytokines and chemokines were significantly higher in the meconium aspiration syndrome group than in the nonmeconium aspiration syndrome group: interleukin-6, interleukin-8, granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor, interferon-gamma, and tumor necrosis factor-alpha. Serum concentrations of interleukin-10 (anti-inflammatory cytokine) in the meconium aspiration syndrome group were higher than those in both the nonmeconium aspiration syndrome group and healthy children group (P = .007 and 0.001, respectively). CONCLUSIONS: Most types of proinflammatory cytokines and chemokines in sera of neonates with meconium aspiration syndrome were higher than those without meconium aspiration syndrome, giving support to the suggestion that elevated levels are associated with the pathogenesis of meconium aspiration syndrome. |
| | |
Authors:
|
Kaoru Okazaki; Masatoshi Kondo; Masahiko Kato; Ryota Kakinuma; Akira Nishida; Masahiro Noda; Kiyosu Taniguchi; Hirokazu Kimura |
Related Documents
:
|
21293699 - Septic shock. 2589429 - Meconium aspiration syndrome: intrapartum and neonatal attributes. 19833459 - Why does meconium cause meconium aspiration syndrome? current concepts of mas pathophys... 22503269 - Successful delivery following icsi with macrocephalic sperm head syndrome: a case report. 19877779 - Transarterial embolization of a scalp hemangioma presenting with kasabach-merritt syndr... 21116509 - Structural peculiarities of epidermal barrier in individuals with syndrome of undiffere... 2526609 - Congenital anomalies of the eustachian tube in down syndrome. histopathologic case report. 9420859 - Gynecologic disorders in women with ehlers-danlos syndrome. 17318849 - Vitreous phenotype: a key diagnostic sign in stickler syndrome types 1 and 2 complicate... |
Publication Detail:
|
Type: Journal Article Date: 2008-03-17 |
Journal Detail:
|
Title: Pediatrics Volume: 121 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-04-02 Completed Date: 2008-04-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
|
Languages: eng Pagination: e748-53 Citation Subset: AIM; IM |
Affiliation:
|
Division of Neonatology, Tokyo Metropolitan Hachioji Children's Hospital, 4-33-13 Daimachi, Hachioji, Tokyo 193-0931, Japan. okazaki@chp.hachioji.tokyo.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Apgar Score Biological Markers / blood Case-Control Studies Chemokines / blood* Cytokines / blood* Female Follow-Up Studies Gestational Age Granulocyte-Macrophage Colony-Stimulating Factor Humans Infant, Newborn Male Meconium Aspiration Syndrome / blood*, diagnosis* Probability Reference Values Risk Assessment Sensitivity and Specificity Severity of Illness Index Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Chemokines; 0/Cytokines; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pediatric residents' clinical and educational experiences with end-of-life care.
Next Document: Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes.