Document Detail


Serum cystatin C in pregnancies with normal and restricted fetal growth.
MedLine Citation:
PMID:  17636214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to investigate circulating levels of cystatin C (an important endogenous marker of renal function) in mothers, fetuses, and neonates from intrauterine growth-restricted (IUGR; characterized by impaired nephrogenesis) and appropriate-for-gestational-age (AGA) pregnancies. Serum cystatin C levels were measured by enzyme immunoassay in 40 parturients and their 20 IUGR (<or=3rd customized centile, due to gestational pathology) and 20 AGA fetuses and neonates on postnatal day 1 (N1) and 4 (N4). Comparatively, creatinine and urea concentrations were determined in the same samples. Fetal cystatin C levels were higher in the AGA than the IUGR group (P = .001). In both groups, maternal cystatin C levels were lower than fetal (P < .001), N1 (P < .001), and N4 (P < .001) levels. Fetal levels were higher than N1 (P < .001) and N4 (P < .001), and N1 levels were higher than N4 (P = .007) ones. In both groups, no correlation existed between maternal and fetal levels, but positive correlations were found between cystatin C, creatinine, and urea levels in maternal and neonatal samples (in all cases, r >or= 0.376 and P <or= .045). Cystatin C levels did not correlate with gestational age and did not differ between males and females. Fetal cystatin C serum levels are lower in the IUGR group, significantly decrease after birth, and do not correlate with maternal levels in both groups. In addition, serum cystatin C levels positively correlate with respective creatinine and urea levels in the perinatal period.
Authors:
Ariadne Malamitsi-Puchner; Despina D Briana; Louiza Kontara; Maria Boutsikou; Stavroula Baka; Demetrios Hassiakos; Antonios Marmarinos; Demetrios Gourgiotis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  14     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Affiliation:
Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece. amalpu@aretaieio.uoa.grmalamitsi@aias.gr
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Birth Weight
Cystatin C
Cystatins / blood*
Female
Fetal Growth Retardation / blood*
Humans
Infant, Newborn
Maternal Age
Parity
Pregnancy / physiology*
Pregnancy Complications / blood*
Reference Values
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CST3 protein, human; 0/Cystatin C; 0/Cystatins

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