| Serum cystatin C in pregnancies with normal and restricted fetal growth. | |
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MedLine Citation:
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PMID: 17636214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to investigate circulating levels of cystatin C (an important endogenous marker of renal function) in mothers, fetuses, and neonates from intrauterine growth-restricted (IUGR; characterized by impaired nephrogenesis) and appropriate-for-gestational-age (AGA) pregnancies. Serum cystatin C levels were measured by enzyme immunoassay in 40 parturients and their 20 IUGR (<or=3rd customized centile, due to gestational pathology) and 20 AGA fetuses and neonates on postnatal day 1 (N1) and 4 (N4). Comparatively, creatinine and urea concentrations were determined in the same samples. Fetal cystatin C levels were higher in the AGA than the IUGR group (P = .001). In both groups, maternal cystatin C levels were lower than fetal (P < .001), N1 (P < .001), and N4 (P < .001) levels. Fetal levels were higher than N1 (P < .001) and N4 (P < .001), and N1 levels were higher than N4 (P = .007) ones. In both groups, no correlation existed between maternal and fetal levels, but positive correlations were found between cystatin C, creatinine, and urea levels in maternal and neonatal samples (in all cases, r >or= 0.376 and P <or= .045). Cystatin C levels did not correlate with gestational age and did not differ between males and females. Fetal cystatin C serum levels are lower in the IUGR group, significantly decrease after birth, and do not correlate with maternal levels in both groups. In addition, serum cystatin C levels positively correlate with respective creatinine and urea levels in the perinatal period. |
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Authors:
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Ariadne Malamitsi-Puchner; Despina D Briana; Louiza Kontara; Maria Boutsikou; Stavroula Baka; Demetrios Hassiakos; Antonios Marmarinos; Demetrios Gourgiotis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 14 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-09-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 37-42 Citation Subset: IM |
Affiliation:
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Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece. amalpu@aretaieio.uoa.grmalamitsi@aias.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Birth Weight Cystatin C Cystatins / blood* Female Fetal Growth Retardation / blood* Humans Infant, Newborn Maternal Age Parity Pregnancy / physiology* Pregnancy Complications / blood* Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CST3 protein, human; 0/Cystatin C; 0/Cystatins |
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