| Serum creatinine is an inadequate screening test for renal failure in ischemic stroke patients. | |
| | |
MedLine Citation:
|
PMID: 19486327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Serum creatinine (SCr) level is the most commonly used screening test for renal function, but its concentration is affected by factors other than glomerular filtration rate (GFR). We hypothesized that SCr would underestimate the degree of renal failure in ischemic stroke patients. MATERIAL AND METHODS: We conducted a prospective study of 273 patients admitted to our institution for ischemic stroke within a year. GFR was calculated using the Cockcroft-Gault formula (CG). Patients were grouped according to the SCr with stages of renal failure according to CG values. RESULTS: Of the 273 patients studied, 231 had normal SCr. Of this group 46.8% (108), 24.7% (57) and 4 (1.7%) had mild, moderate and severe renal failure according to GFR estimation. Among patients with normal SCr, abnormal CG values were identified in 86.2% (150) > or = 65 years old, 33.3% (19) <65 years old, 69% (89) in men and 78.4% (80) in women. An SCr greater than 1.7 mg/dl had only a sensitivity of 14.7%. CONCLUSIONS: This study documents the substantial prevalence of significantly abnormal renal function among patients with normal-range SCr. Routine estimation of GFR be preferred to SCr as a screening method for the early detection of renal impairment in stroke patients. |
| | |
Authors:
|
G Piñol-Ripoll; I de la Puerta; F Purroy |
Related Documents
:
|
21943027 - The promise study: a phase 2b multicenter study of voclosporin (isa247) versus tacrolim... 23433047 - Renal transplantation after ex vivo normothermic perfusion: the first clinical study. 2157277 - Initial effect of enalapril on kidney function in patients with moderate to severe chro... 1912407 - Assessing the progression of renal disease in clinical studies: effects of duration of ... 17112627 - Curative bone marrow transplantation in erythropoietic protoporphyria after reversal of... 21709957 - Islet transplantation in rodents. do encapsulated islets really work? |
Publication Detail:
|
Type: Journal Article Date: 2009-04-13 |
Journal Detail:
|
Title: Acta neurologica Scandinavica Volume: 120 ISSN: 1600-0404 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-06-16 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
|
Languages: eng Pagination: 47-52 Citation Subset: IM |
Affiliation:
|
Neurology Division, Hospital Santa Maria, Rovira Roure no. 44, Lleida, Spain. gerard_437302@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Brain Ischemia / complications* Creatinine / blood* Female Glomerular Filtration Rate Humans Kidney Failure, Chronic / blood, complications*, diagnosis* Male Middle Aged Prospective Studies Stroke / blood, complications* |
| Chemical | |
Reg. No./Substance:
|
60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration ass...
Next Document: Adults with Tourette's syndrome with and without attention deficit hyperactivity disorder.